Use of Alternative Antiplatelet Agents for Clopidogrel Hypersensitivity

Author(s): Ayesha Ather , Craig J. Beavers* .

Journal Name: Current Vascular Pharmacology

Volume 17 , Issue 2 , 2019

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Graphical Abstract:


Abstract:

Clopidogrel is a widely used agent for secondary prevention of vascular events and is a cornerstone of dual antiplatelet therapy in patients with acute coronary syndrome (ACS) post coronary stent implantation. Hypersensitivity reactions to clopidogrel are well documented and may range from localized to systemic in presentation. This can lead to discontinuation of therapy, thus increasing the risk of vascular events. The authors have developed recommendations for potential alternative agents for the management of clopidogrel hypersensitivity reactions. Proposed strategies include treatment with an alternative P2Y12 inhibitor, cilostazol or warfarin.

Keywords: Clopidogrel, hypersensitivity, prasugrel, ticagrelor, cilostazol, warfarin, stenting, rash.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2019
Page: [127 - 132]
Pages: 6
DOI: 10.2174/1570161116666180730100806
Price: $58

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