Medicinal Importance of Azo and Hippuric Acid Derivatives

Author(s): Tehreem Tahir, Muhammad Ashfaq*, Humna Asghar, Mirza I. Shahzad, Rukhsana Tabassum, Areeba Ashfaq.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 9 , 2019

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Graphical Abstract:


In this review, specific therapeutic and medicinal advantages including antiviral, antibacterial, antifungal and antitumor, strategies for drug designing, structure-activity relationship, advances in the syntheses of azo and hippuric acid derivatives of more than 50 compounds have been discussed since 2009-2018. It is found that phenyl-diazenyl azo derivatives and pyridinyl substituted hippuric acid derivatives showed promising antiretroviral potential. The incorporation of azo functionality to the respective quinolones and coumarin moieties and the insertion of thiocarbazone to hippuric acid displayed immense antibacterial activities. While, azo and hippuric acid derivatives of triazole and phenyl species gave maximum fungicidal as well as cytotoxic activities.

Keywords: Drug targets, azo dyes, hippuric acid derivatives, synthetic chemistry, antiviral drugs, anti-microbial agents.

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Year: 2019
Page: [708 - 719]
Pages: 12
DOI: 10.2174/1389557518666180727162018
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