Nanoparticles as Therapeutic Delivery Systems in Relation to Cancer Diagnosis and Therapy

Author(s): Narges Dastmalchi, Reza Safaralizadeh*, Saeid Latifi-Navid.

Journal Name: Current Nanoscience

Volume 15 , Issue 3 , 2019

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Graphical Abstract:


Background: In recent years, nanotechnology has been known as an integrated knowledge collection which involves various fields. One of the developing fields of nanotechnology which has achieved significant approval is named nanobiotechnology. Nanobiotechnology is a combined form of biology and nanotechnology that incorporates the synthesis of nanoparticles(NPs) that are less than 100nm in size and have following use in biological applications.

Objective: The present review study is focused on the variety of nanocarriers and their use in biomedicine and tumor diagnosis and treatment.

Results: Conventional therapeutic drugs have exhibited substantial limitations. Therefore, significant attainments have efficiently been made in nanobiotechnology for delivering drugs to the position of action, and reducing their side-effects and limiting radiation therapy toward tumorous sites. So far, several polymeric nanocarriers integrating cytotoxic therapeutics have been made. There is a need for modulation of size and surface features of NPs because unchanged NPs are cleaned from blood circulation. In order to increase biological distribution of therapeutic drugs, irradiation effect, and better tumor imaging, several modified nanocarriers have been developed in optimum size as well as altered external part.

Conclusion: In this way, NP is known as an efficient and alternative approach for various aims, including drug delivery, PTT, gene therapy, imaging and diagnosis. There is an anticipation about the contribution of NPs in the field of efficient cancer treatment. Furthermore, NPs may be a proper approach in the treatment of other diseases such as HIV/AIDS. The present review focuses on the variety of nanocarriers and their use in biomedicine and tumor diagnosis and treatment.

Keywords: Nano-biotechnology, nanoparticles, biological usages, therapeutic drugs, irradiation, tumor imaging.

Rao, L.; Cai, B.; Bu, L.L.; Liao, Q.Q.; Guo, S.S.; Zhao, X.Z.; Dong, W.F.; Liu, W. Microfluidic electroporation facilitated synthesis of erythrocyte membrane-coated magnetic nanoparticles for enhanced imaging-guided cancer therapy. ACS Nano, 2017, 11, 3496-3505.
Sadreddini, S.; Safaralizadeh, R.; Baradaran, B.; Aghebati-Maleki, L.; Hosseinpour-Feizi, M.A.; Shanehbandi, D.; Jadidi-Niaragh, F.; Sadreddini, S.; Kafil, H.S.; Younesi, V.; Yousefi, M. Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer. Immunol. Lett., 2017, 181, 79-86.
Suri, S.S.; Fenniri, H.; Singh, B. Nanotechnology-based drug delivery systems. J. Occup. Med. Toxicol., 2007, 2, 16.
Hainfeld, J.F.; Dilmanian, F.A.; Slatkin, D.N.; Smilowitz, H.M. Radiotherapy enhancement with gold nanoparticles. J. Pharm. Pharmacol., 2008, 60, 977-985.
Drouet, F.; Lagrange, J. Normal tissue tolerance to external beam radiation therapy: Bone marrow. Cancer Radiother., 2010, 14, 392-404.
Minchinton, A.I.; Tannock, I.F. Drug penetration in solid tumours. Nat. Rev. Cancer, 2006, 6, 583-592.
Bahrami, B.; Mohammadnia-Afrouzi, M.; Bakhshaei, P.; Yazdani, Y.; Ghalamfarsa, G.; Yousefi, M.; Sadreddini, S.; Jadidi-Niaragh, F.; Hojjat-Farsangi, M. Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy. Tumour Biol., 2015, 36, 5727-5742.
Xie, J.; Liu, G.; Eden, H.S.; Ai, H.; Chen, X. Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc. Chem. Res., 2011, 44, 883-892.
Pedrosa, P.; Vinhas, R.; Fernandes, A.; Baptista, P.V. Gold Nanotheranostics: Proof-of-concept or clinical tool? Nanomaterials (Basel), 2015, 5, 1853-1879.
Shi, X.Y.; Fan, X.G. Advances in nanoparticle system for deliverying drugs across the biological barriers. J. China Pharm. Univ., 2002, 33, 169-172.
Mironava, T.; Hadjiargyrou, M.; Simon, M.; Jurukovski, V.; Rafailovich, M.H. Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time. Nanotoxicology, 2010, 4, 120-137.
Barabadi, H.; Alizadeh, A.; Ovais, M.; Ahmadi, A.; Shinwari, Z.K.; Saravanan, M. Efficacy of green nanoparticles against cancerous and normal cell lines: A systematic review and meta-analysis. IET Nanobiotechnol., 2018, 12, 377-391.
Ovais, M.; Khalil, A.T.; Raza, A.; Islam, N.U.; Ayaz, M.; Saravanan, M.; Ali, M.; Ahmad, I.; Shahid, M.; Shinwari, Z.K. Multifunctional theranostic applications of biocompatible green- synthesized colloidal nanoparticles. Appl. Microbiol. Biotechnol., 2018, 102, 4393-4408.
Saravanan, M.; Gopinath, V.; Chaurasia, M.K.; Syed, A.; Ameen, F.; Purushothaman, N. Green synthesis of anisotropic zinc oxide nanoparticles with antibacterial and cytofriendly properties. Microb. Pathog., 2018, 115, 57-63.
Saravanan, M.; Jacob, V.; Jesu, A.; Prakash, P. Extracellular biosynthesis, characterization and antibacterial activity of silver nanoparticles synthesized by Bacillus subtilis (NCIM—2266). J. Bionanosci., 2014, 8, 21-27.
Rezaee, Z.; Yadollahpour, A.; Bayati, V.; Negad Dehbashi, F. Gold nanoparticles and electroporation impose both separate and synergistic radiosensitizing effects in HT-29 tumor cells: An in vitro study. Int. J. Nanomedicine, 2017, 12, 1431-1439.
Wang, F.; Li, L.; Liu, B.; Chen, Z.; Li, C. Hyaluronic acid decorated pluronic P85 solid lipid nanoparticles as a potential carrier to overcome multidrug resistance in cervical and breast cancer. Biomed. Pharmacother., 2017, 86, 595-604.
Ovais, M.; Khalil, A.T.; Raza, A.; Khan, M.A.; Ahmad, I.; Islam, N.U.; Saravanan, M.; Ubaid, M.F.; Ali, M.; Shinwari, Z.K. Green synthesis of silver nanoparticles via plant extracts: Beginning a new era in cancer theranostics. Nanomedicine (Lond.), 2016, 11, 3157-3177.
Saravanan, M.; Asmalash, T.; Gebrekidan, A.; Gebreegziabiher, D.; Araya, T.; Hilekiros, H.; Barabadi, H.; Ramanathan, K. Nano-medicine as a newly emerging approach to combat Human Immunodeficiency Virus (HIV). Pharm. Nanotechnol., 2018, 6, 17-27.
Zamboni, C.G.; Kozielski, K.L.; Vaughan, H.J.; Nakata, M.M.; Kim, J.; Higgins, L.J.; Pomper, M.G.; Green, J.J. Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma. J. Control. Release, 2017, 263, 18-28.
Rawat, M.; Singh, D.; Saraf, S.; Saraf, S. Nanocarriers: Promising vehicle for bioactive drugs. Biol. Pharm. Bull., 2006, 29, 1790-1798.
Seifi-Najmi, M.; Hajivalili, M.; Safaralizadeh, R.; Sadreddini, S.; Esmaeili, S.; Razavi, R.; Ahmadi, M.; Mikaeili, H.; Baradaran, B.; Shams-Asenjan, K.; Yousefi, M. SiRNA/DOX lodeded chitosan based nanoparticles: Development, characterization and in vitro evaluation on A549 lung cancer cell line. Cell. Mol. Biol.(Noisy-legrand)., 2016, 62, 87-94.
Ahmadi Nasab, N.; Hassani Kumleh, H.; Beygzadeh, M.; Teimourian, S.; Kazemzad, M. Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment. Artif. Cells Nanomed. Biotechnol., 2018, 46, 75-81.
Eivazy, P.; Atyabi, F.; Jadidi-Niaragh, F.; Aghebati Maleki, L.; Miahipour, A.; Abdolalizadeh, J.; Yousefi, M. The impact of the codelivery of drug-siRNA by trimethyl chitosan nanoparticles on the efficacy of chemotherapy for metastatic breast cancer cell line (MDA-MB-231). Artif. Cells Nanomed. Biotechnol., 2017, 45, 889-896.
Ghaz-Jahanian, M.A.; Abbaspour-Aghdam, F.; Anarjan, N.; Berenjian, A.; Jafarizadeh-Malmiri, H. Application of chitosan-based nanocarriers in tumor-targeted drug delivery. Mol. Biotechnol., 2015, 57, 201-218.
Mignani, S.; El Kazzouli, S.; Bousmina, M.; Majoral, J.P. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview. Adv. Drug Deliv. Rev., 2013, 65, 1316-1330.
Dabrzalska, M.; Benseny-Cases, N.; Barnadas-Rodríguez, R.; Mignani, S.; Zablocka, M.; Majoral, J.P.; Bryszewska, M.; Klajnert-Maculewicz, B.; Cladera, J. Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimers. Anal. Bioanal. Chem., 2016, 408, 535-544.
Lv, T.; Yu, T.; Fang, Y.; Zhang, S.; Jiang, M.; Zhang, H.; Zhang, Y.; Li, Z.; Chen, H.; Gao, Y. Role of generation on folic acid-modified poly (amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. Mater. Sci. Eng. C Mater. Biol. Appl., 2017, 75, 182-190.
Xu, L.; Andrew Yeudall, W.; Yang, H. Folic acid-decorated polyamidoamine dendrimer exhibits high tumor uptake and sustained highly localized retention in solid tumors: Its utility for local siRNA delivery. Acta Biomater., 2017, 57, 251-261.
Zilio, S.; Vella, J.L.; De la Fuente, A.C.; Daftarian, P.M.; Weed, D.T.; Kaifer, A.; Marigo, I.; Leone, K.; Bronte, V.; Serafini, P. 4PD functionalized dendrimers: A flexible tool for in vivo gene silencing of tumor-educated myeloid cells. J. Immunol., 2017, 198, 4166-4177.
Kong, L.; Xing, L.; Zhou, B.; Du, L.; Shi, X. Dendrimer-modified MoS2 nanoflakes as a platform for combinational gene silencing and photothermal therapy of tumors. ACS Appl. Mater. Interfaces, 2017, 9, 15995-16005.
Hou, Y.; Yao, C.; Ling, L.; Du, Y.; He, R.; Ismail, M.; Zhang, Y.; Fu, Z.; Li, X. Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency. Colloids Surf. B Biointerfaces, 2017, 156, 29-37.
Soga, O.; van Nostrum, C.F.; Fens, M.; Rijcken, C.J.; Schiffelers, R.M.; Storm, G.; Hennink, W.E. Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. J. Control. Release, 2005, 103, 341-353.
Nakanishi, T.; Fukushima, S.; Okamoto, K.; Suzuki, M.; Matsumura, Y.; Yokoyama, M.; Okano, T.; Sakurai, Y.; Kataoka, K. Development of the polymer micelle carrier system for doxorubicin. J. Control. Release, 2001, 74, 295-302.
Tang, M.; Hu, P.; Zhen, Q.; Tirelli, N.; Yang, X.; Wang, Z.; Wang, Y.; Tang, Q.; He, Y. Polymeric micelles with dual thermal and reactive oxygen species (ROS)-responsiveness for inflammatory cancer cell delivery. J. Nanobiotechnol, 2017, 15, 39.
Trubetskoy, V.S.; Gazelle, G.S.; Wolf, G.L.; Torchilin, V.P. Block-copolymer of polyethylene glycol and polylysine as a carrier of organic iodine: Design of long-circulating particulate contrast medium for X-ray computed tomography. J. Drug Target., 1997, 4, 381-388.
Aji Alex, M.R.; Nehate, C.; Veeranarayanan, S.; Kumar, D.S.; Kulshreshtha, R.; Koul, V. Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy. Biomaterials, 2017, 133, 94-106.
Wen, D.; Peng, Y.; Lin, F.; Singh, R.K.; Mahato, R.I. Micellar delivery of miR-34a modulator rubone and paclitaxel in resistant prostate cancer. Cancer Res., 2017, 77, 3244-3254.
Blanco, E.; Kessinger, C.W.; Sumer, B.D.; Gao, J. Multifunctional micellar nanomedicine for cancer therapy. Exp. Biol. Med. (Maywood), 2009, 234, 123-131.
Norouzi, M.; Nazari, B.; Miller, D.W. Injectable hydrogel-based drug delivery systems for local cancer therapy. Drug Discov. Today, 2016, 21, 1835-1849.
Mano, J.F. Stimuli‐responsive polymeric systems for biomedical applications. Adv. Eng. Mater., 2008, 10, 515-527.
Kim, D.Y.; Kwon, D.Y.; Kwon, J.S.; Park, J.H.; Park, S.H.; Oh, H.J.; Kim, J.H.; Min, B.H.; Park, K.; Kim, M.S. Synergistic anti-tumor activity through combinational intratumoral injection of an in-situ injectable drug depot. Biomaterials, 2016, 85, 232-245.
Shu, C.; Li, R.; Yin, Y.; Yin, D.; Gu, Y.; Ding, L.; Zhong, W. Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo. Chem. Commun. (Camb.), 2014, 50, 15423-15426.
Rezaee, Z.; Yadollahpour, A.; Bayati, V.; Negad Dehbashi, F. Gold nanoparticles and electroporation impose both separate and synergistic radiosensitizing effects in HT-29 tumor cells: An in vitro study. Int. J. Nanomedicine, 2017, 12, 1431-1439.
Sun, M.; Peng, D.; Hao, H.; Hu, J.; Wang, D.; Wang, K.; Liu, J.; Guo, X.; Wei, Y.; Gao, W. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces, 2017, 9, 10453-10460.
Dimitriou, N.M.; Tsekenis, G.; Balanikas, E.C.; Pavlopoulou, A.; Mitsiogianni, M.; Mantso, T.; Pashos, G.; Boudouvis, A.G.; Lykakis, I.N.; Tsigaridas, G.; Panayiotidis, M.I.; Yannopapas, V.; Georgakilas, A.G. Gold nanoparticles, radiations and the immune system: Current insights into the physical mechanisms and the biological interactions of this new alliance towards cancer therapy. Pharmacol. Ther., 2017, 178, 1-17.
Ahmad, B.; Hafeez, N.; Bashir, S.; Rauf, A. Mujeeb-Ur-Rehman. Phytofabricated gold nanoparticles and their biomedical applications. Biomed. Pharmacother., 2017, 89, 414-425.
Cao, Q.; Liu, X.; Yuan, K.; Yu, J.; Liu, Q.; Delaunay, J.J.; Che, R. Gold nanoparticles decorated Ag (Cl,Br) micro-necklaces for efficient and stable SERS detection and visible-light photocatalytic degradation of Sudan I. Appl. Catal. B Environ, 2017, 201, 607-616.
Xue, H.Y.; Liu, Y.; Liao, J.Z.; Lin, J.S.; Li, B.; Yuan, W.G.; Lee, R.J.; Li, L.; Xu, C.R.; He, X.X. Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma. Oncotarget, 2016, 7, 86675-86686.
Yang, X.; Ouyang, Y.; Wu, F.; Hu, Y.; Ji, Y.; Wu, Z. Size-controllable preparation of gold nanoparticles loading on graphene sheets@cerium oxide nanocomposites modified gold electrode for nonenzymatic hydrogen peroxide detection. Sens. Actuators B Chem., 2017, 238, 40-47.
Sun, M.; Liu, F.; Zhu, Y.; Wang, W.; Hu, J.; Liu, J.; Dai, Z.; Wang, K.; Wei, Y.; Bai, J.; Gao, W. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale, 2016, 8, 4452-4457.
Zhang, X.F.; Liu, Z.G.; Shen, W.; Gurunathan, S. Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int. J. Mol. Sci., 2016, 17, E1534.
Subbaiya, R.; Saravanan, M.; Priya, A.R.; Shankar, K.R.; Selvam, M.; Ovais, M.; Balajee, R.; Barabadi, H. Biomimetic synthesis of silver nanoparticles from Streptomyces atrovirens and their potential anticancer activity against human breast cancer cells. IET Nanobiotechnol., 2017, 11, 965-972.
Thorley, A.J.; Tetley, T.D. New perspectives in nanomedicine. Pharmacol. Ther., 2013, 140(2), 176-185.
Gopinath, P.; Gogoi, S.K.; Chattopadhyay, A.; Ghosh, S.S. Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy. Nanotechnology, 2008, 19, 075104.
Kelkar, S.S.; Reineke, T.M. Theranostics: Combining imaging and therapy. Bioconjug. Chem., 2011, 22, 1879-1903.
Thapa, R.K.; Kim, J.H.; Jeong, J.H.; Shin, B.S.; Choi, H.G.; Yong, C.S.; Kim, J.O. Silver nanoparticle-embedded graphene oxide-methotrexate for targeted cancer treatment. Colloids Surf. B Biointerfaces, 2017, 153, 95-103.
Pattni, B.S.; Chupin, V.V.; Torchilin, V.P. New developments in liposomal drug delivery. Chem. Rev., 2015, 115, 10938-10966.
Wang, X.F.; Witting, P.K.; Salvatore, B.A.; Neuzil, J. Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. Biochem. Biophys. Res. Commun., 2005, 326, 282-289.
Ling, L.; Du, Y.; Ismail, M.; He, R.; Hou, Y.; Fu, Z.; Zhang, Y.; Yao, C.; Li, X. Self-assembled liposomes of dual paclitaxel-phospholipid prodrug for anticancer therapy. Int. J. Pharm., 2017, 526, 11-22.
Li, X.; Ruan, G.R.; Lu, W.L.; Hong, X.Y.; Liang, G.W.; Zhang, Y.T.; Liu, Y.; Long, C.; Ma, X.; Yuan, L.; Wang, J.C.; Zhang, X.; Zhang, Q. A novel stealth liposomal topotecan with amlodipine: Apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia. J. Control. Release, 2006, 112, 186-198.
Mu, L.M.; Ju, R.J.; Liu, R.; Bu, Y.Z.; Zhang, J.Y.; Li, X.Q.; Zeng, F.; Lu, W.L. Dual-functional drug liposomes in treatment of resistant cancers. Adv. Drug Deliv. Rev., 2017, 115, 46-56.
Nguyen, H.T.; Tran, T.H.; Thapa, R.K.; Phung, C.D.; Shin, B.S.; Jeong, J.H.; Choi, H.G.; Yong, C.S.; Kim, J.O. Targeted co-delivery of polypyrrole and rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy. Int. J. Pharm., 2017, 527, 61-71.
Wang, M.; Zhao, T.; Liu, Y.; Wang, Q.; Xing, S.; Li, L.; Wang, L.; Liu, L.; Gao, D. Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy. Mater. Sci. Eng. C Mater. Biol. Appl., 2017, 71, 1231-1240.
Wong, H.L.; Bendayan, R.; Rauth, A.M.; Li, Y.; Wu, X.Y. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv. Drug Deliv. Rev., 2007, 59, 491-504.
Shi, S.; Han, L.; Deng, L.; Zhang, Y.; Shen, H.; Gong, T.; Zhang, Z.; Sun, X. Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J. Control. Release, 2014, 194, 228-237.
Madan, J.; Pandey, R.S.; Jain, V.; Katare, O.P.; Chandra, R.; Katyal, A. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine , 2013, 9, 492-503.
Shi, S.; Han, L.; Gong, T.; Zhang, Z.; Sun, X. Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew. Chem. Int. Ed. Engl., 2013, 52, 3901-3905.
Jang, D.J.; Moon, C.; Oh, E. Improved tumor targeting and antitumor activity of camptothecin loaded solid lipid nanoparticles by preinjection of blank solid lipid nanoparticles. Biomed. Pharmacother., 2016, 80, 162-172.
Liu, M.; Chen, D.; Wang, C.; Chen, X.; Wen, Z.; Cao, Y.; He, H. Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance. J. Drug Target., 2015, 23, 800-805.
Kuang, Y.; Zhang, K.; Cao, Y.; Chen, X.; Wang, K.; Liu, M.; Pei, R. Hydrophobic IR-780 dye encapsulated in cRGD-conjugated solid lipid nanoparticles for NIR imaging-guided photothermal therapy. ACS Appl. Mater. Interfaces, 2017, 9, 12217-12226.
Geszke-Moritz, M.; Moritz, M. Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies. Mater. Sci. Eng. C Mater. Biol. Appl., 2016, 68, 982-994.
Li, J.; Wang, S.; Shi, X.; Shen, M. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci., 2017, 249, 374-385.
Pilapong, C.; Keereeta, Y.; Munkhetkorn, S.; Thongtem, S.; Thongtem, T. Enhanced doxorubicin delivery and cytotoxicity in multidrug resistant cancer cells using multifunctional magnetic nanoparticles. Colloids Surf. B Biointerfaces, 2014, 113, 249-253.
Barahuie, F.; Dorniani, D.; Saifullah, B.; Gothai, S.; Hussein, M.Z.; Pandurangan, A.K.; Arulselvan, P.; Norhaizan, M.E. Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system. Int. J. Nanomedicine, 2017, 12, 2361-2372.
Samanta, B.; Yan, H.; Fischer, N.O.; Shi, J.; Jerry, D.J.; Rotello, V.M. Protein-passivated Fe(3)O(4) nanoparticles: Low toxicity and rapid heating for thermal therapy. J. Mater. Chem., 2008, 18, 1204-1208.
Radenkovic, D.; Kobayashi, H.; Remsey-Semmelweis, E.; Seifalian, A.M. Quantum dot nanoparticle for optimization of breast cancer diagnostics and therapy in a clinical setting. Nanomedicine , 2016, 12, 1581-1592.
Sun, Z.; Zhao, Y.; Li, Z.; Cui, H.; Zhou, Y.; Li, W.; Tao, W.; Zhang, H.; Wang, H.; Chu, P.K.; Yu, X.F. TiL4 -coordinated black phosphorus quantum dots as an efficient contrast agent for in vivo photoacoustic imaging of cancer. Small, 2017, 13(11), 1602896.
Zhao, M.X.; Zhu, B.J. The research and applications of quantum dots as nano-carriers for targeted drug delivery and cancer therapy. Nanoscale Res. Lett., 2016, 11, 207.
Iannazzo, D.; Pistone, A.; Salamò, M.; Galvagno, S.; Romeo, R.; Giofré, S.V.; Branca, C.; Visalli, G.; Di Pietro, A. Graphene quantum dots for cancer targeted drug delivery. Int. J. Pharm., 2017, 518, 185-192.
Chen, Q.; Liu, Z. Albumin carriers for cancer theranostics: A conventional platform with new promise. Adv. Mater., 2016, 28, 10557-10566.
Green, M.R.; Manikhas, G.M.; Orlov, S.; Afanasyev, B.; Makhson, A.M.; Bhar, P.; Hawkins, M.J. Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer. Ann. Oncol., 2006, 17, 1263-1268.
Miller, K.; Wang, M.; Gralow, J.; Dickler, M.; Cobleigh, M.; Perez, E.A.; Shenkier, T.; Cella, D.; Davidson, N.E. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med., 2007, 357, 2666-2676.
Zhang, Y.; Yang, Z.; Tan, X.; Tang, X.; Yang, Z. Development of a more efficient albumin-based delivery system for Gambogic acid with low toxicity for lung cancer therapy. AAPS PharmSciTech, 2017, 18, 1987-1997.
Gao, F.P.; Lin, Y.X.; Li, L.L.; Liu, Y.; Mayerhöffer, U.; Spenst, P.; Su, J.G.; Li, J.Y.; Würthner, F.; Wang, H. Supramolecular adducts of squaraine and protein for noninvasive tumor imaging and photothermal therapy in vivo. Biomaterials, 2014, 35, 1004-1014.
Chen, Q.; Liang, C.; Wang, X.; He, J.; Li, Y.; Liu, Z. An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery. Biomaterials, 2014, 35, 9355-9362.
Chen, Q.; Wang, X.; Wang, C.; Feng, L.; Li, Y.; Liu, Z. Drug-induced self-assembly of modified albumins as nano-theranostics for tumor-targeted combination therapy. ACS Nano, 2015, 9, 5223-5233.
Chu, D.; Dong, X.; Zhao, Q.; Gu, J.; Wang, Z. Photosensitization priming of tumor microenvironments improves delivery of nanotherapeutics via neutrophil infiltration. Adv. Mater., 2017, 29
Javey, A.; Guo, J.; Wang, Q.; Lundstrom, M.; Dai, H. Ballistic carbon nanotube field-effect transistors. Nature, 2003, 424, 654-657.
Wang, N.; Feng, Y.; Zeng, L.; Zhao, Z.; Chen, T. Functionalized multiwalled carbon nanotubes as carriers of ruthenium complexes to antagonize cancer multidrug resistance and radioresistance. ACS Appl. Mater. Interfaces, 2015, 7, 14933-14945.
Son, K.H.; Hong, J.H.; Lee, J.W. Carbon nanotubes as cancer therapeutic carriers and mediators. Int. J. Nanomedicine, 2016, 11, 5163-5185.
Li, R.; Wu, R.; Zhao, L.; Wu, M.; Yang, L.; Zou, H. P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells. ACS Nano, 2010, 4, 1399-1408.
Tian, Z.; Yin, M.; Ma, H.; Zhu, L.; Shen, H.; Jia, N. Supramolecular assembly and antitumor activity of multiwalled carbon nanotube–camptothecin complexes. J. Nanosci. Nanotechnol., 2011, 11, 953-958.
Wu, W.; Li, R.; Bian, X.; Zhu, Z.; Ding, D.; Li, X.; Jia, Z.; Jiang, X.; Hu, Y. Covalently combining carbon nanotubes with anticancer agent: Preparation and antitumor activity. ACS Nano, 2009, 3, 2740-2750.
Chen, C.; Xie, X.X.; Zhou, Q.; Zhang, F.Y.; Wang, Q.L.; Liu, Y.Q.; Zou, Y.; Tao, Q.; Ji, X.M.; Yu, S.Q. EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide. Nanotechnology, 2012, 23, 045104.
Chou, H.T.; Wang, T.P.; Lee, C.Y.; Tai, N.H.; Chang, H.Y. Photothermal effects of multiwalled carbon nanotubes on the viability of BT-474 cancer cells. Mater. Sci. Eng. C, 2013, 33, 989-995.
Gidcumb, E.; Gao, B.; Shan, J.; Inscoe, C.; Lu, J.; Zhou, O. Carbon nanotube electron field emitters for X-ray imaging of human breast cancer. Nanotechnology, 2014, 25, 245704.
Cheng, J.; Meziani, M.J.; Sun, Y.P.; Cheng, S.H. Poly (ethylene glycol)-conjugated multi-walled carbon nanotubes as an efficient drug carrier for overcoming multidrug resistance. Toxicol. Appl. Pharmacol., 2011, 250, 184-193.
Xiong, L.Q.; Chen, Z.G.; Yu, M.X.; Li, F.Y.; Liu, C.; Huang, C.H. Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors. Biomaterials, 2009, 30, 5592-5600.
Cui, S.; Yin, D.; Chen, Y.; Di, Y.; Chen, H.; Ma, Y.; Achilefu, S.; Gu, Y. In vivo targeted deep tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct. ACS Nano, 2013, 7, 676-688.
Sun, Y.; Zhu, X.; Peng, J.; Li, F. Core-shell lanthanide upconversion nanophosphors as four-modalprobes for tumor angiogenesis imaging. ACS Nano, 2013, 7, 11290-11300.
Ang, L.Y.; Lim, M.E.; Ong, L.C.; Zhang, Y. Applications of upconversion nanoparticles in imaging, detection and therapy. Nanomedicine (Lond.), 2011, 6, 1273-1288.
Chatterjee, D.K.; Rufaihah, A.J.; Zhang, Y. Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials, 2008, 29, 937-943.
Gai, S.; Yang, P.; Li, C.; Wang, W.; Dai, Y.; Niu, N.; Lin, J. Synthesis of magnetic, up-conversion luminescent, and mesoporous core-shell-structured nanocomposites as drug carriers. Adv. Funct. Mater., 2010, 20, 1166-1172.
Jiang, S.; Zhang, Y.; Lim, K.M.; Sim, E.K.; Ye, L. NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA. Nanotechnology, 2009, 20, 155101.
Yuan, Q.; Venkatasubramanian, R.; Hein, S.; Misra, R.D. A stimulus-responsive magnetic nanoparticle drug carrier: Magnetite encapsulated by chitosan-grafted-copolymer. Acta Biomater., 2008, 4, 1024-1037.
Gerion, D.; Pinaud, F.; Williams, S.C.; Parak, W.J.; Zanchet, D.; Weiss, S.; Alivisatos, A.P. Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J. Phys. Chem. B, 2001, 105, 8861-8871.
Soenen, S.J.; Parak, W.J.; Rejman, J.; Manshian, B. (Intra)cellular stability of inorganic nanoparticles: Effects on cytotoxicity, particle functionality, and biomedical applications. Chem. Rev., 2015, 115, 2109-2135.
Peer, D.; Karp, J.M.; Hong, S.; Farokhzad, O.C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol., 2007, 2, 751-760.

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Article Details

Year: 2019
Page: [218 - 233]
Pages: 16
DOI: 10.2174/1573413714666180727094825
Price: $58

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