Background: The rising number of health problems and diseases leads to demands and
medical advancement. These increasing demands have led us to work on catalysis which ultimately
increases the yield of pharmaceutically important drugs.
Methods: Synthesis of 9, 10-diarylacridine-1, 8-dione has been carried out by single-pot, efficient and
environmentally benign Hantzsch condensation reaction, which includes three component reactants
i.e. aldehyde, amine and 5, 5-Dimethyl-1, 3- cyclohexanedione (dimedone). Zeolite LTL has been
synthesized and modified by using three different metal oxides i.e. SrO, CuO and Cr2O3. Comparative
studies based on %yield at varying parameters have been performed with different metal oxide modified
zeolite-LTL which signifies the catalytic efficiency of various metal oxides and H-form zeolite.
The competency of nanoporous modified zeolite-LTL has also been observed under various parameters
(i.e. different solvent, temperature, catalyst concentration, time interval and catalytic recycling)
with respect to the percentage yield of various compounds.
Results: The synthesized nanoporous zeolites have been characterized by the help of Fourier Transform
Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), BET Surface Area and Porosity Analysis
and Scanning Electron Microscopy- Energy dispersive X-ray spectroscopy (SEM-EDX) while the
structures of the drug derivatives have been confirmed by Fourier Transform Infrared Spectroscopy
(FTIR), 1H-Nuclear Magnetic Resonance Spectroscopy (1H-NMR) and Liquid Chromatography-Mass
spectrometer (LC-MS). XRD, FT-IR and BET studies confirmed that the structure of zeolite hadn’t
deformed/altered by incorporation of metal oxide nanoparticles. Also, BET and XRD results confirmed
the mesoporous structure of zeolite LTL. The reactivity was found highest in ethanol with HLTL
at 90°C for 60 min. i.e. 89.88%.
Conclusion: The main advantages were short reaction time, excellent yield, low catalyst loading, high
purity of the products due to the heterogeneous and harmless properties of zeolite. The protonated
form of zeolite was found to be highly reactive due to presence of high surface area and greater number
of active acid sites (Bronsted Active sites). The expeditious yield has been achieved by using catalysts
which can be helpful to fulfill the demands of increasing health problems. The recyclability, heterogeneous
nature and thermal stability of zeolites also increase the merit of this protocol.