Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus

Author(s): Linghuan Li, Jiameng Qi, Hanbing Li*.

Journal Name: Current Drug Targets

Volume 20 , Issue 1 , 2019

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Graphical Abstract:


Autophagy is a conserved, regulated cellular process for the degradation of abnormal proteins and disrupted organelles. Literature has described that dysregulation of autophagy is closely related to the pathogenesis of diabetes mellitus in processes such as impaired pancreatic β cells function, peripheral insulin resistance and diabetic complications. Emerging evidence indicates that natural products may possess anti-diabetic activity via regulation of autophagy. In this review, we summarize natural products targeting the pathogenesis of diabetes mellitus through the regulation of autophagy and underline possible mechanisms, providing potential drug candidates or therapies for the treatment of diabetes mellitus.

Keywords: Autophagy, diabetes mellitus, insulin resistance, natural products, diabetic complication, pathogenesis.

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Article Details

Year: 2019
Page: [96 - 110]
Pages: 15
DOI: 10.2174/1389450119666180726115805
Price: $58

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PDF: 28