The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene

Author(s): Viktor S. Kokhan , Tat`yana G. Kokhan , Anna N. Samsonova , Vladimir P. Fisenko , Aleksey A. Ustyugov , Gjumrakch Aliev* .

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 17 , Issue 8 , 2018

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Abstract:

Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.

Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.

Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.

Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.

Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.

Keywords: Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2018
Page: [604 - 607]
Pages: 4
DOI: 10.2174/1871527317666180726095734
Price: $58

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