Background: Existing cancer chemotherapeutics can kill normal as well as malignant
cells. To solve these issues, scientists are now more concerned about the design and discovery of
potential anticancer, least toxic leads, which can promote apoptosis process and inhibition of abnormal
signal transduction via hyperactivation of protein kinases such as Pim-1 due to overexpression
or mutation of proto-oncogenes and tumor suppressor genes related to molecular
mechanisms of senescence, cell cycle, apoptosis and metastatic invasion, thus leading to anticancer
activities. Natural scaffolds play a great role in this aspect.
Objective: Sea is full of biodiverse natural resources of medicinal compounds derived from marine
plants, sponges, actinomycetes, cynobacteria, fungi, corals and animals. Many anticancer
compounds were successfully discovered. But there are few potent compounds developed against
abnormal signal transduction mechanism.
Method: Therefore, an attempt has been made in the present review to focus on molecular mechanisms
of various targets in connection with the over-expression of Pim-1 mediated senescence,
cell cycle, apoptosis and metastatic invasion and their potent inhibitors.
Results: Biochemical mechanisms of the potent marine sourced inhibitors keeping activities
against abnormal signal transduction were discussed in this study. It gives great attention to expand
the capabilities in these upcoming areas to remain globally relevant.
Conclusion: Existed marine sourced anticancer compounds tabulated in this study could be used
as a template for further design and synthesis of promising congeneric synthetic compounds
against another disease by the application of in silico high throughput screening through drug repositioning.