Metabolomics is widely applied for investigation of the correlation between metabolites
and genes responsible for the synthesis of the particular sets of metabolites. In this review, we discuss
metabolomics research on Hypericum perforatum (St. John’s Wort) to elucidate the overall
regulation of the metabolism related to the mechanisms of natural variations and environmental
stresses such as fungal infections, light stresses, and chemical elicitors. We also focus on phytochemical
genomics and genomic information. St. John’s Wort is a medicinal plant with high potential
of producing hypericin used for mild depression remedy, so knowledge on the biosynthetic
pathway of unique metabolites is fundamental for their biotechnological commercial production.
These metabolites have often complex biosynthetic pathway and it is challenging to identify all of
the catalyzing enzymes. The development of metabolic systems biology could open new channels
for high- speed construction and evaluation of hypotheses for cellular regulatory systems.
Keywords: Hypericum perforatum, Metabolism, Phytochemical genomics, Hypericin
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