The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in
the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a
major role in oncogenesis as well as its well-known function in the regulation of immune responses
and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the
NF-κB pathway is constitutively activated in different types of human cancers and the potential role of
various oncogenic genes regulated by this transcription factor in cancer development and progression.
We also discussed various pharmacological approaches employed to target the deregulated NF-κB
signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen
tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a
variety of transmembrane receptors including classical immune-receptors like the B-cell receptor
(BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines
and cytokines in the presence of pathogens would be discussed as well. The highlight of this review
article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling
and then raise some possibilities for cancer therapy.
Keywords: NF-κB, Syk, signaling pathway, cancer, therapy, tumor necrosis factor.
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