Background: Leukoaraiosis (LA) is a common radiological finding in elderly,
frequently associated with several clinical disorders, including unexplained dizziness.
The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation
resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this
Objective: The aim of this study was to analyse some oxidative stress biomarkers in a
cohort of LA patients.
Method: Fifty-five consecutive patients (33 males, median age 75 years) with LA were
recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then
performed an open study to evaluate if 60-day supplementation with a polyphenol
compound may modify these biomarkers and influence quality of life, analysed with the
Dizziness Handicap Inventory (DHI) scale.
Results: At baseline, blood oxidative stress parameters values were outside normal
ranges and compared to matched healthy controls. After the two months
supplementation, we observed a significant decrement of advanced oxidation protein
products values and a significant improvement of DHI.
Conclusion: Oxidative stress biomarkers may be useful to detect redox imbalance in LA
and to provide non-invasive tools to monitor disease status and response to therapy.