Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target

Author(s): Chi-yuan Zhang, Mo liu, Jia-ming Wan, Ming-qi Gao, Yue Zhang, Muscab Soyan, Huai-Liang Wang, Yang Bai*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 12 , 2018

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Abstract:

Pulmonary arterial hypertension (PAH) is a devastating disease without effective drugs available for its treatment. An in-depth exploration of the pathogenesis of PAH, as well as inquiry into potential therapeutic targets, remains an urgent issue. Non-coding RNAs (ncRNAs) have arisen as key players in malignant tumors, cardiovascular diseases and more recently in PAH progression and development. Network pharmacology is a new discipline based on system biology, which can predict potential therapeutic targets in diseases regulated by multiple genes. In this review, we discuss the current knowledge of ncRNAs and network pharmacology regulated genes involved in PAH, as well as the search for potential drug targets for PAH.

Keywords: Pulmonary arterial hypertension, Noncoding RNA, Drugs, miRNA, LncRNA, Network.

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Article Details

VOLUME: 18
ISSUE: 12
Year: 2018
Page: [975 - 986]
Pages: 12
DOI: 10.2174/1568026618666180719162124
Price: $58

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