Background: Gastrointestinal (GI) diseases are a major cause of emergency department visits requiring
hospitalizations leading to considerable burden on global economy. Several factors contribute to the onset of
gastrointestinal diseases such as pathogens (parasites, bacteria, virus, toxins etc.), autoimmune disorders and
severe inflammation of intestine.
Objective: One common feature among all these diseases is the dysentery and alteration of gut microbiota composition
(gut dysbiosis). Apart from conventional therapies such as antibiotics and ORS supplementation, gut microbiota
modulation with probiotic supplementation has emerged as a successful and healthy alternative in mitigating
GI diseases. In this review our goal is to discuss the causes of gastrointestinal diseases and the present state
of various therapeutic strategies such as probiotics as live biotherapeutics and Fecal Microbial Transplants
Conclusion: Several reports and clinical trials point out to the beneficial effects of probiotics in modulating the
gut microbiota and improving the side effects of gastrointestinal diseases. Live biotherapeutics and FMT’s could
be suitable and successful alternatives to conventional therapies in mitigating the gastrointestinal pathogens.