Background: Sudden Cardiac Death (SCD) is an unexpected death caused by heart dysfunction.
Autoantibodies against cardiac proteins may be potentially involved in the occurrence and
progression of cardiac disease and SCD. The first report on the role of autoantibodies in idiopathic
dilated cardiomyopathy appeared in the 1980s. In recent years new studies on the effects of the
presence of specific autoantibodies and their relationship to ventricular arrhythmias and SCD were
published. The purpose of the current mini-review is to analyze the results of the research studies
focused on the relationship between anti-cardiomyocyte autoantibodies and SCD with respect to
Conclusion: According to our analysis, more research is needed to understand the role of these
autoantibodies against cardiac proteins in the SCD pathogenesis, and potentially employ this
knowledge for improving prognosis of SCD.
Keywords: Sudden cardiac death, autoantibodies, channels, autoimmune disorders, heart dysfunction, cardiomyopathy.
Rights & PermissionsPrintExport