Attachment of different tails to the well-known carbonic anhydrase (CA) pharmacophores
has led to the development of several new CA inhibitors (CAIs). A very good example
of such “tails” is constituted by carbohydrates, which represent a wide range of chemotypes,
leading thus to a high number of new CAIs. In the last years, several C-cinnamoyl glycosides
containing different scaffolds have been prepared and investigated as carbonic anhydrase
inhibitors, showing that some of them are very potent and selective CAIs. This article
will review the latest developments in the synthesis and biological activity of these Cglycosides.
Keywords: Carbohydrate, enzyme inhibition, antitumoral, tuberculosis, heterocycle, CAIs, carbonic anhydrase.
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