Role of Morin in Neurodegenerative Diseases: A Review

Author(s): Ritu Kataria, Eduardo Sobarzo-Sanchez*, Anurag Khatkar*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 11 , 2018

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Abstract:

Neurodegenerative diseases are likely to emerge as the second cause of mortality in the world in coming years. NDDs cause tremendous financial burden on the healthcare system along with profound effect on families and patient. Disease-modifying treatment strategies with proven efficacy for these disorders are still lacking. Documentation proved that oxidative stress plays a leading role in the pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have been well recognized in the literature. Morin being super antioxidant compound helped in preventing and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review, we tried to explain various neuropathological conditions with their target sites and neurobiological mechanisms of morin.

Keywords: Morin, Neurodegenerative disease, Herbal, Polyphenolic compound, Flavonoid, Alzheimer`s disease.

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Article Details

VOLUME: 18
ISSUE: 11
Year: 2018
Page: [901 - 907]
Pages: 7
DOI: 10.2174/1568026618666180711153416
Price: $58

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