Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

Title:Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

Volume: 5 Issue: 2

Author(s): Srinivas L. Nakkalwar, Shivaji B. Patwari, Mohasim M. Patel and Vivekanand B. Jadhav*

Affiliation:

• Department of Chemistry, Shri Muktanand College, Gangapur, Dist.-Aurangabad, (MH), Pin-431 109,India

Keywords: Aromatic aldehydes containing an electron donating groups, hydroxylamine hydrochloride, ethyl acetoacetate, 4- arylidene-3-methylisoxazol-5(4H)-ones, iodine & water.

Abstract: An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out. The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation reaction was performed in water, which is an environmentally benign universal solvent having unique properties being clean, efficient, inexpensive, and readily available.

Cite this article as:

Nakkalwar L. Srinivas, Patwari B. Shivaji, Patel M. Mohasim and Jadhav B. Vivekanand *, Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium, Current Green Chemistry 2018; 5 (2) . https://dx.doi.org/10.2174/2213346105666180711151320