An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine
hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out.
The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent
yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation
reaction was performed in water, which is an environmentally benign universal solvent
having unique properties being clean, efficient, inexpensive, and readily available.
Keywords: Aromatic aldehydes containing an electron donating groups, hydroxylamine hydrochloride, ethyl acetoacetate, 4-
arylidene-3-methylisoxazol-5(4H)-ones, iodine & water.
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