Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

Author(s): Srinivas L. Nakkalwar, Shivaji B. Patwari, Mohasim M. Patel, Vivekanand B. Jadhav*.

Journal Name: Current Green Chemistry

Volume 5 , Issue 2 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out. The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation reaction was performed in water, which is an environmentally benign universal solvent having unique properties being clean, efficient, inexpensive, and readily available.

Keywords: Aromatic aldehydes containing an electron donating groups, hydroxylamine hydrochloride, ethyl acetoacetate, 4- arylidene-3-methylisoxazol-5(4H)-ones, iodine & water.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 5
ISSUE: 2
Year: 2018
Page: [122 - 128]
Pages: 7
DOI: 10.2174/2213346105666180711151320
Price: $25

Article Metrics

PDF: 32
HTML: 3