Something Old, Something New and Something Used in Alzheimer's; the Idea of Pore, Ethanol and the Use of Oocytes to Understand the Disease

Author(s): Jorge Parodi*.

Journal Name: Current Chemical Biology

Volume 13 , Issue 2 , 2019

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Graphical Abstract:


Background: Alzheimer's disease remains an unsolved public health problem. Recent studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic failure, including a large group of pathologies called peptide misfolding diseases.

Objective: In this line, recent research has proposed new models to study the pathologies such as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate alcohol consumption with a reduced risk of developing neurodegenerative diseases.

Methods: We reviewed the latest publication in this field.

Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.

Keywords: Alzheimer, synapses, calcium, pore, oocytes, peptide misfolding diseases.

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Article Details

Year: 2019
Page: [105 - 109]
Pages: 5
DOI: 10.2174/2212796812666180710125905
Price: $58

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