Something Old, Something New and Something Used in Alzhei-mer's; the Idea of Pore, Ethanol and the Use of Oocytes to Under-stand the Disease

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Author(s): Jorge Parodi*.

Journal Name: Current Chemical Biology

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Background: Alzheimer's disease remains an unsolved public health problem. Recent studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic failure, including a large group of pathologies called peptide misfolding diseases. Objective: In this line, recent research has proposed new models to study the pathologies such as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate alcohol con-sumption with a reduced risk of developing neurodegenerative diseases. Method: We reviewed the latest publication in this field. Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.

Keywords: Alzheimer, Synapses, Calcium, pore, oocytes, peptide misfolding diseases

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(E-pub Ahead of Print)
DOI: 10.2174/2212796812666180710125905
Price: $95