Introduction: Schizophrenia is seizures accompanied by severe psychotic symptoms, and a
steady state of continuation in the form of periods of stagnation. Antipsychotics are now the basis of
treatment for schizophrenia and there is no other molecule that is antipsychotic priority in treatment.
Antipsychotics can be classified into two groups; dopamine receptor antagonists such as promazine,
fluphenazine etc. and serotonin-dopamine antagonists including risperidone, olanzapine, ziprasidone,
Materials and Methods: Electrochemical methods have been used for the determination of antipsychotic
agent just as used in the determination of many drug agents. Nearly all of the antipsychotics are
electroactive and can be analyzed by electrochemical methods. Electroanalytical methods offer generally
high sensitivity, are compatible with modern techniques, have low cost, low requirements, and
compact design. Among the most commonly used types, there are cyclic voltammetry, differential pulse
voltammetry, square wave voltammetry and linear sweep voltammetry.
Conclusion: The aim of this review is to evaluate the main line and the advantages and uses of electroanalytical
methods that employed for the determination of antipsychotic medication agents used in
schizophrenia. Moreover, applications of the methods to pharmaceutical analysis of Antipsychotics upto-
date is also summarized in a table.