Introduction: Cancer is the one of the current leading cause of death all over the world.
Among the various emerging technologies, nanotechnology plays a prominent role in delivering the
drug to the target region.
Materials & Methods: Hence, in this study, the In vitro effect of doxorubicin adsorbed gold nanoparticles
synthesized by Azadirachta Indica leaves extract as reducing agent and the doxorubicin entrapped
modified liposomes called transfersomes was compared over the cervical cancer cell line
(HeLa cell lines). The synthesized gold nanoparticles were characterized using a UV-visible spectrophotometer,
Results: The UV-Visible spectrum showed the peak at 537nm and the incorporation of drug over the
nanoparticles was conformed using FTIR and SEM analysis. The drug entrapment onto transfersomes
was also characterized using FTIR and SEM analysis. When compared, the drug entrapped transfersomes
shows significant effect with the lowest concentration of drug (0.25 μg/mL) than the drug adsorbed
Conclusion: Hence, the transfersomes may also become the promising drug carrier in the future.
Keywords: Gold nanoparticles , green synthesis , transfersomes , doxorubicin , cervical cancer
Rights & PermissionsPrintExport