Aim: The aim of the present study was to evaluate the protective effect of ferulic
acid in monosodium glutamate-induced anxiety and motor incoordination.
Method: Laca BALB/c mice of either sex were treated intraperitoneally with test drug:Ferulic
acid (100 & 200 mg/kg), inducer: Monosodium glutamate (100mg/kg) along with Diazepam
(2 mg/kg) intraperitoneally as a standard anxiolytic drug and then exposed to Elevated plus
maze, Hole board and Mirror chamber models.
Results: The test drug shows a significant reduction in motor activity and enhances the open
arm exploratory time in elevated plus maze model. This drug increases the number of head
dips in hole board model. It also enhances the number of entries and time spent in the mirror
chamber. All of the changes were highly significant.
Conclusion: The present study concludes that Ferulic acid shows significant anxiolytic
activity at the dose of 100 and 200 mg/kg against monosodium glutamate-induced anxiety
and motor incoordination.