Background: Inflammation is a protective response of the body system that protects the
body from the various kinds of external and internal insults; however, it has been found that most
chronic illnesses are caused by dysregulated and excessive inflammation. Inflammation plays a major
role in developing neurological diseases. In the brain cytokines, TNF-α and TNF-β are known to mediate
inflammation in many diseases. Functions of these cytokines are regulated by the activation of transcription
factor NF-κb. Recent evidence suggest that curcumin has an immense therapeutic potential
because of its anti-inflammatory and anti-oxidant properties. It has been tested for treating various
chronic illnesses associated with the brain.
Objective: The study aims to elucidate the role of curcumin in alleviating the inflammatory reactions
initiated by TNF-α and NF-κb signaling.
Methods: This study is a survey of literature from sources like PubMed central, science direct, medline
and available scientific databases to determine how inflammation plays an important role in the development
of neurodegenerative diseases and the role of curcumin as an anti-inflammatory agent. Looking
into the importance of curcumin in alleviating inflammatory responses, several patents are filed and
accepted which are referenced in this article.
Results: Neuro-inflammation mediated by TNF-α plays a major role in the development of pathologies
like Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis etc. Curcumin
appears to subside or reduce the inflammatory responses. Thus, it appears to have therapeutic
potential for treating various neuroinflammatory diseases.
Conclusion: Cytokines get upregulated during neurodegenerative diseases as a result of which inflammatory
responses are initiated in the brain. Curcumin is reported to have anti-inflammatory properties
and thereby its supplementation may help in reducing the inflammation. Future research on this area
will further explain the mode of action of curcumin in alleviating neuroinflammation.