The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging
topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations,
as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents
display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive
overview of the available literature on C. sativa constituents activities in neuroinflammation is given.
On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent,
we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit
the “entourage effect” in neuroinflammatory-related conditions.
Keywords: Cannabis sativa L., neuroinflammation, cannabinoids, caryophyllene, apigenin, microglia, endocannabinoid
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