Cannabis sativa L. Constituents and Their Role in Neuroinflammation

Author(s): Vittoria Borgonetti , Paolo Governa* , Monica Montopoli , Marco Biagi .

Journal Name: Current Bioactive Compounds

Volume 15 , Issue 2 , 2019

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Graphical Abstract:


Abstract:

The interest in Cannabis sativa L. phytocomplex as a medicinal tool is a recently-emerging topic. Neurodegenerative diseases represent a promising field of application for cannabis and its preparations, as most of this pathologic conditions relies on an inflammatory etiology. Several cannabis constituents display anti-inflammatory effects targeting multiple pathways. In this review, a comprehensive overview of the available literature on C. sativa constituents activities in neuroinflammation is given. On the basis that the anti-inflammatory activity of cannabis is not attributable to only a single constituent, we discuss the possible advantages of administering the whole phytocomplex in order to fully exploit the “entourage effect” in neuroinflammatory-related conditions.

Keywords: Cannabis sativa L., neuroinflammation, cannabinoids, caryophyllene, apigenin, microglia, endocannabinoid system, phytotherapy.

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VOLUME: 15
ISSUE: 2
Year: 2019
Page: [147 - 158]
Pages: 12
DOI: 10.2174/1573407214666180703130525
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