Magnetically Recoverable Nano Sulfated Titania Catalysed One Pot Synthesis of 4(3H)-quinazolinone Derivatives

Title:Magnetically Recoverable Nano Sulfated Titania Catalysed One Pot Synthesis of 4(3H)-quinazolinone Derivatives

Volume: 7 Issue: 3

Author(s): Sandip S. Sabale and Mariam S. Degani*

Affiliation:

• Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai- 400019,India

Keywords: Magnetic nanoparticles, nano sulfated TiO2, solid acid catalyst, quinazolinone, microwave, amines.

Abstract: Intoduction: A highly efficient protocol for the one pot synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters and various amines using a magnetically separable solid acid catalyst, nano sulfated TiO2 encapsulated Fe3O4 with microwave irradiation, is described. The plausible reaction mechanism for the synthesis of 4(3H)-quinazolinone, catalyzed by sulfated TiO2 encapsulated magnetic nanomaterial is also described.

Conclusion: The developed process has been successfully applied for the synthesis of diverse 4(3H)- quinazolinones with variable functionality. This approach overcomes many of the drawbacks of the existing methods and provides an environmentally benign process.

Cite this article as:

Sabale S. Sandip and Degani S. Mariam*, Magnetically Recoverable Nano Sulfated Titania Catalysed One Pot Synthesis of 4(3H)-quinazolinone Derivatives, Current Catalysis 2018; 7 (3) . https://dx.doi.org/10.2174/2211544707666180702125931