Myocardial ischemia is the consequence of an unbalance between coronary flow that can be achieved
and myocardial metabolic needs. Pathological state of both epicardial and intramyocardial vessels may be responsible
for inducing ischemia. However, revascularization decision should be based on the severity of each epicardial
lesion that is evaluated. There are different diagnostic tools that may help for the evaluation of each compartment
which is based on the measurement of coronary hemodynamics. Pressure-derived indices are recommended
by current guidelines for evaluation of epicardial stenosis significance. We assess the complex interaction
between hemodynamic parameters in order to understand how different parameters are influenced in the
settings of microvascular dysfunction.
Keywords: Myocardial ischemia, microvascular dysfunction, stenosis severity, FFR, CFR, IMR.
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