Genetic Polymorphism on the Pharmacokinetics and Pharmacodynamics of Plateletderived Growth Factor Receptor (PDGFR) Kinase Inhibitors

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Author(s): Yi Qian, Lei Yu, Xue-Hui Zhang, Qing-Yun Yuan-Zi, Ping Zhao, Lu-ning Sun, Yong-Qing Wang*.

Journal Name: Current Drug Metabolism

Abstract:

Platelet-derived Growth Factor Receptor (PDGFR) is one of the families of Receptor Tyrosine Kinases (RTKs), which have attracted increasing attention as a potential target of antitumor therapy in cancer. PDGFR family members consist of PDGFR-

Keywords: Platelet-derived growth factor receptor, tyrosine kinase inhibitors, small-molecule inhibitors; pharmacokinetics, pharmacodynamics, pharmacogenomics.

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(E-pub Ahead of Print)
DOI: 10.2174/1389200219666180629112943
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