Antibacterial Profile of Copaifera multijuga Oleoresin and Hydroalcoholic Extract of Leaves Against Oral Pathogens

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Author(s): Iane Pereira Pimenta, Fariza Abrao, Jonas Joaquim Mangabeira da Silva, Larissa Oliveira Costa, Herve Louis Ghislain Rogez, Sergio Ricardo Ambrosio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins*.

Journal Name: Current Dentistry

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Background: Copaifera multijuga are widely used as medicinal plants in Brazil. Of the various ethnopharmacological indications of copaiba oleoresins, the antimicrobial activity had been highlighted. Objective: This study aimed to evaluate the oleoresin and the hydroalcoholic extract of leaves from Copaifera multijuga against oral pathogens in the sessile and in the planktonic modes. Method: Standard strains from the American Type Culture Collection and clinical isolates which cause both cariogenic and endodontic infections were used. Results: The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays showed that the oleoresin was effective against all the bacterial strains. Assessment of the antibiofilm activity of hydroalcoholic extract of leaves from C. multijuga against the evaluated microaerophilic bacteria in the sessile mode gave IC50 values of 318.0 and 695.6 μg/mL against S. mitis (ATCC 49456) and A. actinomycetemcomintans (ATCC 43717), respectively. As for the assayed anaerobic bacteria, the hydroalcoholic extract of leaves gave IC50 of 4554.0, 2218.0, and 600.1 μg/mL against F. nucleatum (Clinical isolate), P. gingivalis (ATCC 33277), and P. micros (Clinical isolate), respectively, whereas the oleoresin afforded IC50 of 357.1 μg/mL against P. gingivalis (ATCC 33277). Conclusion: The oleoresin and hydroalcoholic extract of leaves displayed satisfactory activity against oral pathogens in both sessile and planktonic modes. The oleoresin and hydroalcoholic extracts of leaves from C. multijuga are potential candidates for the development of new products for dental and oral care.

Keywords: Copaifera multijuga, dental caries, endodontic infections, biofilm, hydroalcoholic extract, oleoresin

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(E-pub Ahead of Print)
DOI: 10.2174/2542579X01666180629100020

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