Background: Systemic sclerosis is a disorder of connective tissue with unknown cause,
affecting the skin and internal organs, characterized by fibrotic changes.
Objective: To determine the correlation between serum homocysteine level and interstitial lung involvement
in systemic sclerosis.
Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR
classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran,
were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients
were divided into two groups based on interstitial lung involvement and two subtypes, diffuse
and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls,
and cases groups.
Results: Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in
both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and
38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was
13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum
homocysteine level did not differ between the patients with and without interstitial lung involvement
(P=0.52). The patients with lung involvement was older than those without lung involvement
(P=0.004). Lung disease was more common in diffuse type (P=0.014).
Conclusion: In our study, serum homocysteine level did not differ between the patients and healthy
subjects. Also, there was no correlation between serum homocysteine level and lung involvement,
but lung involvement was more common in older patients and also diffuse subtype.