Background: Effective cancer therapy is still a great challenge for modern medical research
due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, and the
limitations commonly associated with currently used cancer therapeutic options. Nanotechnology
has been implemented in cancer therapeutics with immense potential for improving cancer treatment.
Objective: Through information about the recent advances regarding cancer hallmarks, we could
comprehensively understand the pharmacological effects and explore the mechanisms of the interaction
between the nanomaterials, which could provide opportunities to develop mechanism-based
nanomedicine to treat human cancers.
Methods: We collected related information and data from articles.
Results: In this review, we discussed the characteristics of cancer including tumor angiogenesis, abnormalities
in tumor blood vessels, uncontrolled cell proliferation markers, multidrug resistance,
tumor metastasis, cancer cell metabolism, and tumor immune system that provide opportunities and
challenges for nanomedicine to be directed to specific cancer cells and portray the progress that has
been accomplished in application of nanotechnology for cancer treatment.
Conclusion: The information presented in this review can provide useful references for further studies
on developing effective nanomedicine for the treatment of cancer.