Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels
are critical in the generation of action potentials in the nervous system. VGSCs and potassium
channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and
touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia,
parosphresia, and so on.
Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information
processing and discusses the potential role of VGSCs to serve as pharmacological targets for
the treatment of sensory system diseases.