Background & Objective: Continuously active neurogenic regions in the adult brain are located
in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone of the hippocampal
dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters
and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics
may also affect the origin of neuronal cells.
Method: The purpose of this study was to determine the effects of chronic olanzapine treatment on
adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical
and fluorescent detection of sex determining region Y-box 2 and doublecortin expressing
Results & Conclusion: The results indicate that olanzapine has proneurogenic effects on the adult rat
SVZ, as the mean number of sex determining region Y-box 2 and doublecortin-positive cells increased
significantly, while there was a similar tendency in the subgranular zone. Collectively, these results
suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the
SVZ which supports adult neurogenesis.