Coumarins are a class of natural and synthetic products with a wide variety of applications
in different fields. Due to the general importance of coumarins, the objective of this work is to further
develop the chemistry of 1-(2-hydroxy-2-methyl-2H-chromen-3yl)ethanone, 1, a potentially useful and
versatile coumarin but an under-reported compound in the literature. This work describes a green
preparation of 1 in the absence of solvents and acids, thereby eliminating byproducts, normally obtained
in classical procedures, and a mechanistic study of the reactions of 1 with nucleophiles. In addition,
we report the characterisation of 1-(2-ethoxy-2-methyl-2H-chromen-3-yl)ethanone 2, via X-ray
crystallography and 2D NMR spectra.
Keywords: Coumarin, green synthesis, X-ray crystallography, sonochemistry, free solvent, heterocycle.
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