Sensitive Detection of Human Hemoglobin by MWCNTs-ionic Liquid: Anthraquinone Modified Electrode

Author(s): Aghdas Banaei, Mostafa Shourian, Fariba Dashtestani, Khadijeh Eskandari*.

Journal Name: Nanoscience & Nanotechnology-Asia

Volume 9 , Issue 4 , 2019

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Graphical Abstract:


Introduction: Today, nano-composite gels based on multi-walled carbon nanotubes in room temperature ionic liquid (MWCNTs-IL-Gel) are an interesting subject.

Materials and Methods: The nano-composite gels showed convenient electrochemical properties against redox activities of electroactive biomolecules. Also, the evaluation of hemoglobin concentration is a critical point in the clinical sample. So, the kind of nano-composite gel which is composed of NH2 functionalized MWCNTs and [amim] Br IL and anthraquinone 2-carboxilic acid (AQ) was fabricated and applied in electrochemical detection of hemoglobin. Cyclic voltammograms of NH2.MWCNTs-IL-AQ modified electrode exhibited redox peak sat -0.5 V (vs. Ag/AgCl) in 0.1 M phosphate buffer solution ((pH 7.0).

Results: As the hemoglobin added into the measured solution, the redox current decreased.

Conclusion: It can be concluded that the increment in the concentration of hemoglobin caused the decrease in the redox currents in cyclic voltammetry. The NH2.MWCNTs-IL-AQ would detect the concentration of hemoglobin from 1.64 x10−8 to 4.89x10−7 M.

Keywords: Anthraquinone 2-carboxilic acid, electron transferring, hemoglobin, ionic liquid, amine functionalized multi-walled carbon nanotubes.

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Article Details

Year: 2019
Page: [479 - 485]
Pages: 7
DOI: 10.2174/2210681208666180626161341
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