Autophagy is a process the primary role of which is to clear up damaged cellular components
such as long-lived proteins and organelles, thus participating in the conservation of different
cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism
with suppression of bone formation as well as increased bone resorption. In advanced age, not only
bone mass but also bone strength decrease in both sexes, resulting in an increased incidence of fractures.
Clinical and animal experiments reveal that age-related bone loss is associated with many factors
such as accumulation of autophagy, increased levels of reactive oxygen species, sex hormone deficiency,
and high levels of endogenous glucocorticoids. Available basic and clinical studies indicate
that age-associated factors can regulate autophagy. Those factors play important roles in bone remodeling
and contribute to decreased bone mass and bone strength with aging. In this review, we summarize
the mechanisms involved in bone metabolism related to aging and autophagy, supplying a theory
for therapeutic targets to rescue bone mass and bone strength in older people.
Keywords: Age-related osteoporosis, autophagy, BMSCs, osteoblasts, osteoclasts, osteocytes.
Rights & PermissionsPrintExport