Background: Helicobacter pylori (H. pylori)-related gastric diseases are a series of gastric mucosal disorders
associated with H. pylori infection. Gastric cancer (GC) is widely believed to evolve from gastritis and gastric ulcer. As
an important adhesion molecule of epithelial cells, E-cadherin plays a key role in the development of gastric diseases. In
this review, we aim to seek the characteristic of E-cadherin expression at different stages of gastric diseases.
Methods: We searched plenty of databases for research literature about E-cadherin expression in H. pylori-related
gastric diseases, and reviewed the relationship of E-cadherin and H. pylori, and the role of E-cadherin at different
stages of gastric diseases.
Results: H. pylori was shown to decrease E-cadherin expression by various ways in vitro, while most of clinical
studies have not found the relationship between H. pylori and E-cadherin expression. It is defined that poor outcome
of GC is related to loss expression of E-cadherin, but it is still unclear when qualitative change of E-cadherin expression
in gastric mucosa emerges.
Conclusion: Expression level of E-cadherin in gastric cells may be a consequence of injury factors and body’s selfrepairing
ability. More studies on E-cadherin expression in gastric mucosa with precancerous lesions need to be
performed, which may be potential and useful for early detection, prevention and treatment of GC.