Platelet Concentrates in Oral Surgery: Indications and Limits. A Literature Review

Author(s): Gaetano Marenzi*, Med Erda Qorri, Pasquale Sammartino, Filomena Rusciano, Roberta Gasparro.

Journal Name: Current Dentistry

Volume 1 , Issue 1 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: Platelet concentrates (PC) are blood-derived products for local application able to stimulate regeneration in soft and hard tissues, mimicking the physiological healing process. Their efficacy in oral surgical procedures is controversial and limited.

Objective: The study aims to critically analyze the available evidence for the effect of autogenous PC on wound healing of different oral surgical sites reported by more recent clinical studies.

Methods: Electronic and manual searches in three databases (Medline, Web of Science, Scopus) were performed to identify the clinical studies from January 2017 to December 2017 which reported the actual oral surgical indications and the benefit of local application of PC. All human studies evaluating PRP or PRF in a randomized controlled trial, case series, case report and systematic review were included. All animal, histologic and in vitro studies were excluded.

Results: Fifty-two studies were selected. The use of PRF was proposed in treating many oral surgical sites. Data availability with regard to the effect of PRF on new bone formation in GBR and horizontal/ vertical bone augmentation procedures varied from abundant to absent. Positive results concerning the effect of PRF on potential post-surgical complication (pain, swelling and trismus) were reported.

Conclusion: Few clinical indications could be determined: the literature on the topic was contradictory and the published data were difficult to interpret. Positive results were generally recorded for soft tissues and periodontal wound healing. No real benefit of PC application on bone regeneration was evidenced.

Keywords: Bone regeneration, growth factors, osteoblastic activity, Platelet-Rich Fibrin (PRF), Platelet-Rich Plasma (PRP), soft tissue regeneration.

[1]
Del Corso M, Vervelle A, Simonpieri A, et al. Current knowledge and perspectives for the use of platelet- rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Curr Pharm Biotechnol 2012; 13(7): 1207-30.
[2]
Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases 2017; 5(5): 159-71.
[3]
Gasparro R, Qorri E, Valletta A, et al. Non-transfusional hemocomponents: From biology to the clinic-A literature review. Bioengineering (Basel) 2018; 5(2): E27.
[4]
Leo MS, Kumar AS, Kirit R, et al. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol 2015; 14: 315-23.
[5]
Demidova-Rice TN, Wolf L, Deckenback J, et al. Human platelet-rich plasma and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo. PLoS One 2012; 7: 32146.
[6]
Pinto NR, Ubilla M, Zamora Y, et al. Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: A prospective cohort study. Platelets 2017; 20: 1-8.
[7]
Kumar KR, Genmorgan K, Abdul Rahman SM, et al. Role of plasma-rich fibrin in oral surgery. J Pharm Bioallied Sci 2016; 8(Suppl. 1): S36-8.
[8]
Dohan Ehrenfest DM, Bielecki T, Mishra A, et al. In search of a consensus terminology in the field of platelet concentrates for surgical use: Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol 2012; 13(7): 1131-7.
[9]
Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet Rich Plasma: Grow factor enhancement for bone graft. Oral Surg Oral Med Oral Pathol Oral Radioland Endod 1998; 85: 638-46.
[10]
Canellas JVDS, Ritto FG, Medeiros PJD. Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: A systematic review and meta-analysis. Int J Oral Maxillofac Surg 2017; 46(9): 1138-46.
[11]
Miron RJ, Zucchelli G, Pikos MA, et al. Use of platelet-rich fibrin in regenerative dentistry: A systematic review. Clin Oral Investig 2017; 21(6): 1913-27.
[12]
Reed GL. Platelet secretory mechanisms. Semin Thromb Hemost 2004; 30: 441-50.
[13]
Miron RJ, Fujioka-Kobayashi M, Bishara M, et al. Platelet-rich fibrin and soft tissue wound healing: A systematic review. Tissue Eng Part B Rev 2017; 23(1): 83-99.
[14]
Aroca S, Keglevich T, Barbieri B, et al. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study. J Periodontol 2009; 80(2): 244-52.
[15]
Castro AB, Meschi N, Temmerman A, et al. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: Intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta- analysis. J Clin Periodontol 2017; 44(1): 67-82.
[16]
Dohan EDM, Bielecki T, Jimbo R, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol 2012; 13(7): 1145-52.
[17]
Shah R, Shah H, Shetty O, et al. A novel approach to treat peri implantitis with the help of PRF. Pan Afr Med J 2017; 27: 256.
[18]
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol. Oral Radiol Endodontol 2006; 101: e37-44.
[19]
Dohan Ehrenfest DM, Bielecki T, Del Corso M, et al. Shedding light in the controversial terminology for platelet- rich products: Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), platelet-leukocyte gel (PLG), preparation rich in growth factors (PRGF), classification and commercialism. J Biomed Mater Res A 2010; 95(4): 1280-2.
[20]
Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: Current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J 2014; 4(1): 3-9.
[21]
Passaretti F, Tia M, D’Esposito V, et al. Growth-promoting action and growth factor release by different platelet derivatives. Platelets 2014; 25(4): 252-6.
[22]
Ghanaati S, Booms P, Orlowska A, et al. Advanced platelet-rich fibrin: A new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol 2014; 40(6): 679-89.
[23]
Wang X, Zhang Y, Choukroun J, et al. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets 2018; 29(1): 48-55.
[24]
Nanditha S, Chandrasekaran B, Muthusamy S, et al. Apprising the diverse facets of platelet rich fibrin in surgery through a systematic review. Int J Surg 2017; 46: 186-94.
[25]
Castro AB, Meschi N, Temmerman A, et al. Regenerative potential of leucocyte- and platelet-rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review. J Clin Periodontol 2017; 44(2): 225-34.
[26]
Del Fabbro M, Bucchi C, Lolato A, et al. Healing of postextraction sockets preserved with autologous platelet concentrates. A systematic review and meta-analysis. J Oral Maxillofac Surg 2017; 75(8): 1601-15.
[27]
Alzahrani AA, Murriky A, Shafik S. Influence of platelet rich fibrin on post-extraction socket healing: A clinical and radiographic study. Saudi Dent J 2017; 29(4): 149-55.
[28]
Sakio R, Sakamoto Y, Ogata H, et al. Effect of platelet-rich plasma on bone grafting of alveolar clefts. J Craniofac Surg 2017; 28(2): 486-8.
[29]
Yelamali T, Saikrishna D. Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study. J Maxillofac Oral Surg 2015; 14(2): 410-6.
[30]
Hauser F, Gaydarov N, Badoud I, et al. Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: A prospective randomized controlled study. Implant Dent 2013; 22(3): 295-303.
[31]
Chenchev IL, Ivanova VV, Neychev DZ, et al. Application of platelet-rich fibrin and injectable platelet-rich fibrin in combination of bone substitute material for alveolar ridge augmentation - A case report. Folia Med (Plovdiv) 2017; 59(3): 362-6.
[32]
Bhatsange A, Shende A, Deshmukh S, et al. Management of fenestration using bone allograft in conjunction with platelet-rich fibrin. J Indian Soc Periodontol 2017; 21(4): 337-40.
[33]
Chakravarthi S. Platelet rich fibrin in the management of established dry socket. J Korean Assoc Oral Maxillofac Surg 2017; 43(3): 160-5.
[34]
Prataap N, Sunil PM, Sudeep CB, et al. Platelet-rich plasma and incidence of alveolar osteitis in high- risk patients undergoing extractions of mandibular molars: A case-control study. J Pharm Bioallied Sci 2017; 9(Suppl. 1): S173-9.
[35]
Eshghpour M, Danaeifar N, Kermani H, et al. Does intraalveolar application of chlorhexidine gel in combination with platelet-rich fibrin have an advantage over application of platelet- rich fibrin in decreasing alveolar osteitis after mandibular third molar surgery? A double-blinded randomized clinical trial. J Oral Maxillofac Surg. 2017 Dec 16. pii: S0278- 2391(17)31532-X.
[36]
Sharma A, Aggarwal N, Rastogi S, et al. Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). Eur J Dent 2017; 11(4): 508-13.
[37]
Dhote VS, Thosar NR, Baliga SM, et al. Surgical management of large radicular cyst associated with mandibular deciduous molar using platelet-rich fibrin augmentation: A rare case report. Contemp Clin Dent 2017; 8(4): 647-9.
[38]
He Y, Chen J, Huang Y, et al. Local Application of Platelet-Rich Fibrin During Lower Third Molar Extraction Improves Treatment Outcomes. J Oral Maxillofac Surg 2017; 75(12): 2497-506.
[39]
Gülşen U, Şentürk MF. Effect of platelet rich fibrin on edema and pain following third molar surgery: A split mouth control study. BMC Oral Health 2017; 17(1): 79.
[40]
Gandevivala A, Sangle A, Shah D, et al. Autologous platelet-rich plasma after third molar surgery. Ann Maxillofac Surg 2017; 7(2): 245-9.
[41]
Asutay F, Yolcu Ü, Geçör O, et al. An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery. Niger J Clin Pract 2017; 20(12): 1531-6.
[42]
Afat İM, Akdoğan ET, Gönül O. Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on pain, edema, and trismus after surgical extraction of impacted mandibular third molars. J Oral Maxillofac Surg 2017; 2018; 76(5): 926-932
[43]
Al-Hamed FS, Tawfik MA, Abdelfadil E, et al. Efficacy of platelet-rich fibrin after mandibular third molar extraction: A systematic review and meta-analysis. J Oral Maxillofac Surg 2017; 75(6): 1124-35.
[44]
Eshghpour M, Dastmalchi P, Nekooei AH, et al. Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: A double-blinded randomized clinical trial. J Oral Maxillofac Surg 2014; 72(8): 1463-7.
[45]
Gonzalez-Ocasio J, Stevens M. Autotransplantation of third molars with platelet-rich plasma for immediate replacement of extracted non-restorable teeth: A case series. J Oral Maxillofac Surg 2017; 75(9): 1833.
[46]
Zhang Y, Tangl S, Huber CD, et al. Effects of choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study. J Craniomaxillofac Surg 2012; 40(4): 321-8.
[47]
Mihaylova Z, Mitev V, Stanimirov P, et al. Use of platelet concentrates in oral and maxillofacial surgery: An overview. Acta Odontol Scand 2017; 75(1): 1-11.
[48]
Cabbar F, Güler N, Kürkcü M, et al. The effect of bovine bone graft with or without platelet-rich plasma on maxillary sinus floor augmentation. J Oral Maxillofac Surg 2011; 69(10): 2537-47.
[49]
Nizam N, Eren G, Akcalı A, et al. Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study. Clin Oral Implants Res 2018; 29(1): 67-75.
[50]
Cömert Kılıç S, Güngörmüş M, Parlak SN. Histologic and histomorphometric assessment of sinus-floor augmentation with beta-tricalcium phosphate alone or in combination with pure-platelet-rich plasma or platelet- rich fibrin: A randomized clinical trial. Clin Implant Dent Relat Res 2017; 19(5): 959-67.
[51]
Simonpieri A, Choukroun J, Del Corso M, et al. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: A six-year experience. Implant Dent 2011; 20(1): 2-12.
[52]
Öncü E, Kaymaz E. Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation. Clin Implant Dent Relat Res 2017; 19(6): 1009-14.
[53]
Assad M, Bitar W, Alhajj MN. Closure of oroantral communication using platelet-rich fibrin: A report of two cases. Ann Maxillofac Surg 2017; 7(1): 117-9.
[54]
Bilginaylar K. Uncommon odontogenic orocutaneous fistula of the jaw treated with platelet-rich fibrin. Case Rep Dent 2017; 2017: 7174217.
[55]
Taschieri S, Lolato A, Ofer M, et al. Immediate post-extraction implants with or without pure platelet-rich plasma: A 5-year follow-up study. Oral Maxillofac Surg 2017; 21(2): 147-57.
[56]
Tabrizi R, Arabion H, Karagah T. Does platelet-rich fibrin increase the stability of implants in the posterior of the maxilla? A split-mouth randomized clinical trial. Int J Oral Maxillofac Surg 2018; 47(5): 672-5.
[57]
Huang Y, Bornstein MM, Lambrichts I, et al. Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: A concise review and outlook on future possibilities. Int J Oral Sci 2017; 9(1): 1-9.
[58]
Inchingolo F, Cantore S, Dipalma G, et al. Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A clinical and histopathological evaluation. J Biol Regul Homeost Agents 2017; 31(3): 811-6.
[59]
Gönen ZB, Yılmaz Asan C. Treatment of bisphosphonate-related osteonecrosis of the jaw using platelet- rich fibrin. Cranio 2017; 35(5): 332-6.
[60]
Cano-Durán JA, Peña-Cardelles JF, Ortega-Concepción D, et al. The role of leucocyte-rich and platelet- rich fibrin (L-PRF) in the treatment of the medication-related osteonecrosis of the jaws (MRONJ). J Clin Exp Dent 2017; 9(8): e1051-9.
[61]
Park JH, Kim JW, Kim SJ. Does the addition of bone morphogenetic protein 2 to platelet-rich fibrin improve healing after treatment for medication-related osteonecrosis of the jaw? J Oral Maxillofac Surg 2017; 75(6): 1176-84.
[62]
Fornaini C, Cella L, Oppici A, et al. Laser and platelet-rich plasma to treat medication-related osteonecrosis of the jaws (MRONJ): A case report. Laser Ther 2017; 26(3): 223-7.
[63]
Smith OJ, Kanapathy M, Khajuria A, et al. Protocol for a systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing. Syst Rev 2017; 6(1): 111.
[64]
Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: Implications for wound healing. Plast Reconstr Surg 2004; 114(6): 1502-8.
[65]
Picard F, Hersant B, La Padula S, et al. Platelet-rich plasma-enriched autologous fat graft in regenerative and aesthetic facial surgery: Technical note. J Stomatol Oral Maxillofac Surg 2017; 118(4): 228-31.
[66]
Bajaj P, Agarwal E, Rao NS, et al. Autologous platelet-rich fibrin in the treatment of 3-wall intrabony defects in aggressive periodontitis: A randomized controlled clinical trial. J Periodontol 2017; 88(11): 1186-91.
[67]
Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: A randomized split mouth clinical trail. Acta Odontol Scand 2016; 74(1): 36-43.
[68]
Naqvi A, Gopalakrishnan D, Bhasin MT, et al. Comparative evaluation of bioactive glass putty and platelet rich fibrin in the treatment of human periodontal intrabony defects: A randomized control trial. J Clin Diagn Res 2017; 11(7): ZC09-13.
[69]
Agarwal A, Gupta ND. Platelet-rich plasma combined with decalcified freeze-dried bone allograft for the treatment of noncontained human intrabony periodontal defects: A randomized controlled split-mouth study. Int J Periodontics Restorative Dent 2014; 34(5): 705-11.
[70]
Verma UP, Yadav RK, Dixit M, et al. Platelet-rich fibrin: A paradigm in periodontal therapy - a systematic review. J Int Soc Prev Community Dent 2017; 7(5): 227-33.
[71]
Camargo PM, Lekovic V, Weinlaender M, et al. A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans. Int J Periodontics Restorative Dent 2005; 25(1): 49-59.
[72]
Pradeep AR, Bajaj P, Rao NS, et al. Platelet-rich fibrin combined with a porous hydroxyapatite graft for the treatment of 3-wall intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol 2017; 88(12): 1288-96.
[73]
Jain A, Jaiswal GR, Kumathalli K, et al. Comparative evaluation of platelet rich fibrin and dehydrated amniotic membrane for the treatment of gingival recession - A clinical study. J Clin Diagn Res 2017; 11(8): ZC24-8.
[74]
Kurdukar AA, Kurdukar PA, Dani NH. Modified lateral positioned flap with platelet-rich fibrin graft for treatment of denuded root surfaces: A clinical study. Indian J Dent Res 2017; 28(5): 524-9.
[75]
Kuka S, Ipci SD, Cakar G, Yılmaz S. Clinical evaluation of coronally advanced flap with or without platelet-rich fibrin for the treatment of multiple gingival recessions. Clin Oral Investig 2018; 22(3): 1551-8.
[76]
Öncü E. The use of platelet-rich fibrin versus subepithelial connective tissue graft in treatment of multiple gingival recessions: A randomized clinical trial. Int J Periodontics Restorative Dent 2017; 37(2): 265-71.
[77]
Mufti S, Dadawala SM, Patel P, et al. Comparative evaluation of platelet-rich fibrin with connective tissue grafts in the treatment of miller’s class I gingival recessions. Contemp Clin Dent 2017; 8(4): 531-7.
[78]
Samani MK, Saberi BV, Ali Tabatabaei SM, et al. The clinical evaluation of platelet-rich plasma on free gingival graft’s donor site wound healing. Eur J Dent 2017; 11(4): 447-54.
[79]
Uzun BC, Ercan E, Tunalı M. Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions. Clin Oral Investig 2018; 22(3): 1345-54.
[80]
Pazmiño VFC, Rodas MAR, Cáceres CDB, et al. Clinical comparison of the subepithelial connective tissue versus platelet-rich fibrin for the multiple gingival recession coverage on anterior teeth using the tunneling technique. Case Rep Dent 2017; 2017: 4949710.
[81]
Garg S, Arora SA, Chhina S, et al. Multiple gingival recession coverage treated with vestibular incision subperiosteal tunnel access approach with or without platelet-rich fibrin - A case series. Contemp Clin Dent 2017; 8(3): 464-8.
[82]
Burnouf T, Goubran HA, Chen TM, et al. Blood-derived biomaterials and platelet growth factors in regenerative medicine. Blood Rev 2013; 27: 77-89.
[83]
Anitua E, Sánchez M, Orive G, et al. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 2016; 28(31): 4551-60.
[84]
Bielecki T, Dohan Ehrenfest DM. Platelet-rich plasma (PRP) and Platelet-Rich Fibrin (PRF): Surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering. Curr Pharm Biotechnol 2012; 13: 1121-30.
[85]
Cieslik-Bielecka A, Choukroun J, Odin G, et al. L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds. Curr Pharm Biotechnol 2012; 13(7): 1266-77.
[86]
Braccini F, Tardivet L, Dohan Ehrenfest DM. The relevance of Choukroun’s Platelet-Rich Fibrin (PRF) during middle ear surgery: Preliminary results. Rev Laryngol Otol Rhinol (Bord) 2009; 130(3): 175-80.
[87]
Clark D, Rajendran Y, Paydar S, et al. Advanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: A randomized controlled clinical trial. J Periodontol 2018; 89(4): 379-87.
[88]
Torres J, Tamimi FM, Tresguerres IF, et al. Effect of solely applied platelet-rich plasma on osseous regeneration compared to Bio-Oss: A morphometric and densitometric study on rabbit calvaria. Clin Implant Dent Relat Res 2008; 10: 106-12.
[89]
Dohan Ehrenfest DM, Doglioli P, de Peppo GM, et al. Choukroun’s platelet-rich fibrin (PRF) stimulates in vitro proliferation and differentiation of human oral bone mesenchymal stem cell in a dose-dependent way. Arch Oral Biol 2010; 55(3): 185-94.
[90]
Dohan Ehrenfest DM, Del Corso M, Diss A, et al. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol 2010; 81(4): 546-55.
[91]
Anitua E, Prado R, Troya M, et al. Implementation of a more physiological plasma rich in growth factor (PRGF) protocol: Anticoagulant removal and reduction in activator concentration. Platelets 2016; 27(5): 459-66.
[92]
Cabaro S, D’Esposito V, Gasparro R, et al. White cell and platelet content affects the release of bioactive factors in different blood-derived scaffolds. Platelets 2017; 21: 1-5.
[93]
Dohan Ehrenfest DM, Pinto NR, Pereda A, et al. The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane. Platelets 2018; 29(2): 171-84.
[94]
Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: A controlled clinical trial. J Clin Periodontol 2011; 38: 925-32.
[95]
Jankovic S, Aleksic Z, Klokkevold P, et al. Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial. Int J Periodont Restor Dent 2012; 32: e41-50.
[96]
Simonpieri A, Del Corso M, Sammartino G, et al. The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: A new grafting protocol. Implant Dent 2009; 18: 102-11.
[97]
Aricioglu C, Dolanmaz D, Esen A, et al. Histological evaluation of effectiveness of platelet-rich fibrin on healing of sinus membraneperforations: A preclinical animal study. J Craniomaxillofac Surg 2017; 45(8): 1150-7.
[98]
Pinto GDDS, Pigossi SC, Pessoa T, et al. Successful use of leukocyte platelet-rich fibrin in the healing sinus membrane perforation: A case report. Implant Dent 2018; 27(3): 375-80.
[99]
Della Valle A, Sammartino G, Marenzi G, et al. Prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery: Use of platelet-rich plasma gel. J Oral Maxillofac Surg 2003; 61: 1275-8.
[100]
Sammartino G, Tia M, Marenzi G, et al. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J Oral Maxillofac Surg 2005; 63: 766-70.
[101]
Sammartino G, Tia M, Gentile E, et al. Platelet-rich plasma and resorbable membrane for prevention of periodontal defects after deeply impacted lower third molar extraction. J Oral Maxillofac Surg 2009; 67(11): 2369-73.
[102]
Daugela P, Grimuta V, Sakavicius D, et al. Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth randomized clinical trial. Quintessence Int 2018; 49(5): 377-88.
[103]
Varghese MP, Manuel S, Kumar LKS. Potential for osseous regeneration of platelet-rich fibrin-a comparative study in mandibular third molar impaction sockets. J Oral Maxillofac Surg 2017; 75(7): 1322-9.
[104]
Doiphode AM, Hegde P, Mahindra U, et al. Evaluation of the efficacy of platelet-rich plasma and platelet-rich fibrin in alveolar defects after removal of impacted bilateral mandibular third molars. J Int Soc Prev Community Dent 2016; 6(Suppl. 1): S47-52.
[105]
Kumar N, Prasad K, Ramanujam L, et al. Evaluation of treatment outcome after impacted mandibular third molarsurgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study. J Oral Maxillofac Surg 2015; 73(6): 1042-9.
[106]
Marenzi G, Riccitiello F, Tia M, et al. Influence of leukocyte- and platelet-rich fibrin (l-PRF) in the healing of simple postextraction sockets: A split-mouth study. BioMed Res Int 2015; 2015: 369273.
[107]
Sammartino G, Dohan Ehrenfest DM, Carile F, et al. Prevention of hemorrhagic complications after dental extractions into open heart surgery patients under anticoagulant therapy: The use of leukocyte- and platelet-rich fibrin. J Oral Implantol 2011; 37(6): 681-90.
[108]
Simonpieri A, Del Corso M, Vervelle A, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol 2012; 13(7): 1231-56.
[109]
Cieslik-Bielecka A, Dohan Ehrenfest DM, Lubkowska A, et al. Microbicidal properties of Leukocyte- and Platelet-Rich Plasma/Fibrin (L-PRP/L-PRF): New perspectives. J Biol Regul Homeost Agents 2012; 26(2)(Suppl. 1): 43S-52S.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 1
ISSUE: 1
Year: 2019
Page: [12 - 22]
Pages: 11
DOI: 10.2174/2542579X01666180621154507

Article Metrics

PDF: 30
HTML: 4