Objective: Ziziphus jujuba (Z.J) is a medicinal plant with several properties such as antioxidant,
antibacterial, hypnotic and wound healing activity. It also has lowering blood pressure effect
and people use it to treat hypertension. In the present study, the effect of hydroalcoholic extract of Z.J
on cardiovascular parameters in the normotensive rats was investigated.
Materials and Methods: Animal groups include: 1) Sham, only cannulation of artery 2) saline, received
saline for four weeks 3-5) Z.J groups (100, 200 and 400 mg/kg) that treated with Z.J via gavage
for four weeks. In the experiment day (28th Day) femoral artery of all rats cannulated and systolic
blood pressure (SBP), mean atrial pressure (MAP) and heart rate recorded by a power lab system. The
weight of animal in all groups also was recorded in the beginning and the last day of experiment.
Results: There was no significant difference in HR, SBP and MAP parameters between sham and control
groups. The SBP and MAP in higher doses of Z.J (200 and 400mg) significantly decreased compared
to control group. The HR only in dose 200mg of Z.J significantly decreased than the control
Conclusion: The results of present study show that hydroalcoholic extract of Z.J has an inhibitory effect
on basal cardiovascular parameters and its best effects have been shown in dose 200 mg/kg.
Keywords: Ziziphus jujuba, Mean Atrial Pressure, Heart Rate, Systolic Blood Pressure, Rat
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