Background: Arthropods such as scorpion, snake, insects, and spider as well as the marine
animals like sea anemone and cone snails are venomous animals producing venoms with a
complex mixture of peptide, poly peptides and small proteins. The disulfide rich peptides isolated
from these animals are potent substances which specifically and selectively modulate different ion
channels. The significant characteristics of these distinctive pharmacologically potent compounds
highlights the molecular details of their peptide-ion channels interactions as well as provides the
opportunities for the development of novel and natural therapeutic agents to treat various diseases
including neurological disorders also. A good deal is going into the understanding of their therapeutic
applications by unrevealing their mode of action.
Conclusion: In this review, an attempt is made to summarizes the molecular behavior of these
venom peptides, their pattern of interactions that how molecular simulation studies are used to investigate
the dynamic interaction between these peptides and ion channels, structural prediction of
peptide channel complex and calculation of binding free energy.
Keywords: Venom peptides, ion channels, dynamic interaction of venom peptide, ion channels, structural prediction of venom
peptide complex, binding free energy.
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