The number of people who are overweight and obese are continuously increasing both in the adult and
adolescent populations. Coinciding with this is the increased prevalence of health problems such as type 2
diabetes (T2D). Bariatric surgery is the only proven long-term treatment of obesity and may induce remission of
T2D, although the underlying mechanisms are unknown. The translational studies presented here might provide
insight on the mechanism of steady-state energy balance of the obese phenotype using a special time-restricted
feeding regimen for weight loss during the steady-state energy balance; mechanism by vagal blocking therapy
(vBLoc® therapy) as a new treatment for obesity; and possible mechanism behind the remission of T2D
following gastric bypass surgery.
Keywords: Energy balance, PYY, time-restricted feeding, vagus nerve, obese, bariatric surgery.
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