Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

Author(s): Ashish Kumar, Yahya E. Jad, Ayman El-Faham, Beatriz G. de la Torre*, Fernando Albericio*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 1 , 2019

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Abstract:

A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

Keywords: Coupling reagent, phosphonium salts, diethylphosphoryl-OxymaB, hydrolytic stability, solubility.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2019
Page: [30 - 33]
Pages: 4
DOI: 10.2174/1570178615666180612074420
Price: $65

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