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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Efficient CDI/CH3SO3H -Catalyzed, Microwave-Assisted Synthesis of 2-Substituted Benzothiazoles

Author(s): Yao-Wei Li, Pei-Ming Zhang, Rui Li, Yan Bai, Yu Yu* and Zong-Jie Gan*

Volume 16, Issue 1, 2019

Page: [34 - 39] Pages: 6

DOI: 10.2174/1570178615666180611120239

Price: $65

Abstract

CDI combined with CH3SO3H was found to be highly effective for the cyclization of 2-aminothiophenol derivatives with carboxylic acids under MW condition. Fourteen benzothiazole derivatives were synthesized in good yield and their structures were characterized by 1H-NMR, 13CNMR, IR and mass spectrometry. This simple, rapid synthetic method is believed to provide a useful process for the synthesis of 2-substituted benzothiazole compounds.

Keywords: 2-substituted benzothiazoles, CDI/CH3SO3H, 2-aminothiophenol, microwave irradiation, room temperature, mass spectrometry.

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