Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Author(s): Salma E. Ahmed, Nahid Awad, Vinod Paul, Hesham G. Moussa, Ghaleb A. Husseini*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 10 , 2018

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Abstract:

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Keywords: Chemotherapy, multi-drug resistance, anthracyclines, doxorubicin, nano-carriers, ultrasound.

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Article Details

VOLUME: 18
ISSUE: 10
Year: 2018
Page: [857 - 880]
Pages: 24
DOI: 10.2174/1568026618666180608125344
Price: $58

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