Background: Many plant extracts show a synergistic effect with each other or with
modern drugs, the drugs from natural sources contain steroids, flavonoids, glycosides and terpenoid
that have clinical importance for analgesic, anti-inflammatory and antipyretic action.
Objective: The study was designed to evaluate the effective polyphyto admixture TLB for
the analgesic, anti-inflammatory and antipyretic action using different animal model.
Material Methods: The test drug TLB was composed of Polyphyto formulation of Tridax
procumbens, Lawsonia inermis and Bouganvillea spectabilis in four different proportions
[TLB-I (1:1:1), TLB-II (1:1:2), TLB-III (2:1:1), and TLB-IV (1:2:1)]; tested for the analgesic
activity by Hot plate and Tail immersion method, antiinflamatory activity was studied by
using plethysmometer and antipyretic activity was studied by using rectal thermometer at a
dose of 100 mg/kg po.
Results: The result of test drug TLB produced statistically significant effect (<0.05) when it
was studied in Hot plate and Tail immersion method, the inhibition of edema induced by carrageenan
and reduced fever induced by Brewer’s yeast at 100 mg/kg po administration when
compared to the control groups.
Conclusion: Direct crude drug combination of test group TLB containing Tridax procumbens,
Lawsonia inermis and Bougainvillea spectabilis possesses significant analgesic, antiinflammatory
and antipyretic activity.