Study of a Drug (TLB) Containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis for the Effect of Analgesic, Antiinflamatory and Antipyretic Action in Rat

Title:Study of a Drug (TLB) Containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis for the Effect of Analgesic, Antiinflamatory and Antipyretic Action in Rat

Volume: 4 Issue: 4

Author(s): Shibnath Kamila*K. Sravani

Affiliation:

• Department of Pharmacy Practice, Bharat Institute of Technology, Hyderabad,India

Keywords: Tridax procumbens, Lawsonia inermis, Bouganvillea spectabilis, analgesic, anti inflammatory, anti-pyretic activities.

Abstract: Background: Many plant extracts show a synergistic effect with each other or with modern drugs, the drugs from natural sources contain steroids, flavonoids, glycosides and terpenoid that have clinical importance for analgesic, anti-inflammatory and antipyretic action.

Objective: The study was designed to evaluate the effective polyphyto admixture TLB for the analgesic, anti-inflammatory and antipyretic action using different animal model.

Material Methods: The test drug TLB was composed of Polyphyto formulation of Tridax procumbens, Lawsonia inermis and Bouganvillea spectabilis in four different proportions [TLB-I (1:1:1), TLB-II (1:1:2), TLB-III (2:1:1), and TLB-IV (1:2:1)]; tested for the analgesic activity by Hot plate and Tail immersion method, antiinflamatory activity was studied by using plethysmometer and antipyretic activity was studied by using rectal thermometer at a dose of 100 mg/kg po.

Results: The result of test drug TLB produced statistically significant effect (<0.05) when it was studied in Hot plate and Tail immersion method, the inhibition of edema induced by carrageenan and reduced fever induced by Brewer’s yeast at 100 mg/kg po administration when compared to the control groups.

Conclusion: Direct crude drug combination of test group TLB containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis possesses significant analgesic, antiinflammatory and antipyretic activity.

Cite this article as:

Kamila Shibnath*, Sravani K., Study of a Drug (TLB) Containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis for the Effect of Analgesic, Antiinflamatory and Antipyretic Action in Rat, Current Traditional Medicine 2018; 4 (4) . https://dx.doi.org/10.2174/2215083804666180607104804