Study of a Drug (TLB) Containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis for the Effect of Analgesic, Antiinflamatory and Antipyretic Action in Rat

Author(s): Shibnath Kamila* , K. Sravani .

Journal Name: Current Traditional Medicine

Volume 4 , Issue 4 , 2018

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Abstract:

Background: Many plant extracts show a synergistic effect with each other or with modern drugs, the drugs from natural sources contain steroids, flavonoids, glycosides and terpenoid that have clinical importance for analgesic, anti-inflammatory and antipyretic action.

Objective: The study was designed to evaluate the effective polyphyto admixture TLB for the analgesic, anti-inflammatory and antipyretic action using different animal model.

Material Methods: The test drug TLB was composed of Polyphyto formulation of Tridax procumbens, Lawsonia inermis and Bouganvillea spectabilis in four different proportions [TLB-I (1:1:1), TLB-II (1:1:2), TLB-III (2:1:1), and TLB-IV (1:2:1)]; tested for the analgesic activity by Hot plate and Tail immersion method, antiinflamatory activity was studied by using plethysmometer and antipyretic activity was studied by using rectal thermometer at a dose of 100 mg/kg po.

Results: The result of test drug TLB produced statistically significant effect (<0.05) when it was studied in Hot plate and Tail immersion method, the inhibition of edema induced by carrageenan and reduced fever induced by Brewer’s yeast at 100 mg/kg po administration when compared to the control groups.

Conclusion: Direct crude drug combination of test group TLB containing Tridax procumbens, Lawsonia inermis and Bougainvillea spectabilis possesses significant analgesic, antiinflammatory and antipyretic activity.

Keywords: Tridax procumbens, Lawsonia inermis, Bouganvillea spectabilis, analgesic, anti inflammatory, anti-pyretic activities.

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2018
Page: [305 - 314]
Pages: 10
DOI: 10.2174/2215083804666180607104804
Price: $58

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