Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

This reference presents insights into the development of bone marrow aspirate stem cell (BMAC) technology and the potential role of stem cell expansion in the regeneration of damaged and deficient ...
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Role in Non-union and Bone Defects

Pp. 51-59 (9)

Khaled Emara, Ramy Ahmed Diab and Ahmed K. Emara

Abstract

Non-unions occur mostly due to fracture stability, decrease in blood supply, or both. The cause of non-union is subcategorised into biological and mechanical factors. There are several risk factors for non-union which include -but are not limited to smoking, diabetes mellitus, infection, open or compound fractures, senility, inadequate nutrition and some drugs like NSAIDs. Mechanical factors include the application of electric fields, physical stimulation and ultrasound. The biological materials include osteoconductive agents such as tricalcium phosphate (TCP), hydroxyapatite (HA) preferably with added Osteoinductive agents, which enhance migration, proliferation and differentiation of cells to promote fracture healing. Such agents as Platelets rich plasma (PRP), Bone marrow aspirate concentrate (BMAC), and Bone morphogenetic protein (BMP).

Keywords:

Bone defects, Bone Marrow Aspirate Concentrate (BMAC), Delayed union, Expanded stem cells, Fracture, Malunion, MSCs, Non-union.

Affiliation:

Orthopaedic surgery department, Ain Shams University, Cairo, Egypt.