Basic Sciences Behind BMAC and Expanded Stem Cells
Pp. 5-21 (17)
Mohamed Ahmed Mandour, Asmaa Kamal Abdel Maogood, Eman Gamal Ahmed and Rania Mohammed Kishk
Bone Marrow (BM) is a major hematopoietic organ in the human body
being the main primary lymphoid organ; it is the source of production of all blood
lineages. These cells are produced through an interaction between BM hematopoietic
cells and the surrounding microenvironment in a unit called the stem cell niche that
involves several cytokines, growth factors and transcriptional factors. The following
chapter will entail an overview of MSCs, their isolation and clinical application.
Basic Science, Bone Marrow Aspirate, Bone Marrow Aspirate
Concentrate (BMAC), Expanded stem cells, MSCs, Stem cell differentiation.
Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.