Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

This reference presents insights into the development of bone marrow aspirate stem cell (BMAC) technology and the potential role of stem cell expansion in the regeneration of damaged and deficient ...
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Basic Sciences Behind BMAC and Expanded Stem Cells

Pp. 5-21 (17)

Mohamed Ahmed Mandour, Asmaa Kamal Abdel Maogood, Eman Gamal Ahmed and Rania Mohammed Kishk

Abstract

Bone Marrow (BM) is a major hematopoietic organ in the human body being the main primary lymphoid organ; it is the source of production of all blood lineages. These cells are produced through an interaction between BM hematopoietic cells and the surrounding microenvironment in a unit called the stem cell niche that involves several cytokines, growth factors and transcriptional factors. The following chapter will entail an overview of MSCs, their isolation and clinical application.

Keywords:

Basic Science, Bone Marrow Aspirate, Bone Marrow Aspirate Concentrate (BMAC), Expanded stem cells, MSCs, Stem cell differentiation.

Affiliation:

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.