Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents

Author(s): Sarva Santhisudha, Gundluru Mohan, Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy, Cirandur Suresh Reddy*.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 7 , 2019

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Graphical Abstract:


Background: A concatenation of bioactive diethyl(2-hydroxyphenylsubstituted) benzopyrano pyrimidinyl phosphonates were synthesized under eco-friendly green conditions in the presence of palladium doped graphitic carbon nitride (Pd@g-C3N4) as catalyst.

Methods: The title compounds were evaluated for cytotoxic activity against MCF-7, SW-480, HeLa and HL-7702 cell lines and in-vitro antioxidant activity by DPPH, NO and H2O2 methods.

Results: The synthesized compounds manifested robust cytotoxic and antioxidant activities.

Conclusion: Some of them showed much higher bioactivity than the standards.

Keywords: Benzopyranopyrimidinyl phosphonates, one-pot, green synthesis, Pd@g-C3N4, anticancer activity, SRB assay, antioxidant activity, in vitro.

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Year: 2019
Page: [721 - 733]
Pages: 13
DOI: 10.2174/1570180815666180606083418
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