Background: Plant tannins are polyphenolic substances with various molecular
weights and a variable complexity. Due to the beneficial effects for controlling chronic disorders
particularly diabetes mellitus, this class of secondary metabolites has gained more interest
in the recent years.
Objective: We aimed through this review to collect, analyze and discuss all available information
related to the antidiabetic effect of isolated tannins (including both condensed and hydrolysable
varieties) and tannin-rich plants as well as the possible mechanisms of action involved
in this antidiabetic activity.
Methods and Results: Our bibliographic research was conducted to gather more than 41 medicinal
plants containing tannins and 19 isolated tannins and tannin-rich crud extracts which
were revealed to possess glucose lowering effect according to pharmacological studies.
Conclusion: Hence, according to findings of the present review, tannins could be useful for
prevention and management of diabetes mellitus and its associated complications and these
natural products could be promising compounds for the discovery of new hypoglycemic
Keywords: tannins, antidiabetic , condensed tannins , hydrolysable tannins , hypoglycemic , tannin-rich plants.
Rights & PermissionsPrintExport