Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach

Author(s): Satya Karuna Pulakhandam, Annem Siva Reddy, Naresh Kumar Katari*, Ravi Prakash Reddy Manda, Sreekantha B. Jonnalagadda*.

Journal Name: Current Green Chemistry

Volume 5 , Issue 2 , 2018

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Abstract:

Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted thio quinazoline compounds as substrates. All the twelve products were characterized by melting range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.

Keywords: Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2018
Page: [108 - 113]
Pages: 6
DOI: 10.2174/2213346105666180605123417

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