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Current Green Chemistry

Editor-in-Chief

ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

Research Article

Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach

Author(s): Satya Karuna Pulakhandam, Annem Siva Reddy, Naresh Kumar Katari*, Ravi Prakash Reddy Manda and Sreekantha B. Jonnalagadda*

Volume 5, Issue 2, 2018

Page: [108 - 113] Pages: 6

DOI: 10.2174/2213346105666180605123417

Abstract

Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted thio quinazoline compounds as substrates. All the twelve products were characterized by melting range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.

Keywords: Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.

Graphical Abstract

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