Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs
(NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption,
and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal
route is also beneficial for drugs having a narrow therapeutic index. The skin acts as the primary barrier
for transdermal delivery of various therapeutic molecules.
Various advanced nanocarrier systems offer several advantages like improved dermal penetration along
with an extended drug release profile due to their smaller size and high surface area. Various nanocarriers
explored for transdermal delivery of NSAIDs are liposomes, niosomes, ethosomes, polymeric
nanoparticles (NPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), dendrimers,
nanosuspensions/nanoemulsion, and nanofibers.
Objectives: In the present review, our major aim was to explore the therapeutic potential of advanced
nanocarrier systems enlisted above for transdermal delivery of NSAIDs. All literature search regarding
advanced nanocarrier systems for transdermal delivery of NSAIDs was done using Google Scholar and
Conclusions: Advanced nanocarriers have shown various advantages like reduced side effect, low dosing
frequency, high skin permeation, and ease of application over conventional transdermal delivery
systems of NSAIDs in various preclinical studies. However, clinical exploration of advanced nanocarrier
systems for transdermal delivery of NSAIDs is still a challenge.